Top 50 Prescription Drugs Filled in the U.S.

Prescription Drugs

Top 50 Prescription Drugs Filled in the U.S.

Heart Attack.High Cholesterol.Stroke
RxSaver Editors
By RxSaver Editors
Jun 16, 2016
Prescription pills being poured into a pill holder.

Today RxSaver released its list of the top 50 prescription drugs filled in the U.S. in Q1 of 2016. Topping the list is Atorvastatin Calcium, Lipitor’s generic equivalent, which is used to treat high cholesterol. It also lowers the risk of stroke and heart attack, among other risk factors.

The top five filled drugs treat a growing number of Americans with high cholesterol, thyroid disorders, high blood pressure, GERD and type 2 diabetes. The other drugs rounding out the top 10 also treat high blood pressure, as well as high cholesterol and chronic pain.

Use the RxSaver tool below to search discounted coupons at nearby pharmacies.

Top 10 Rx Drugs Filled in the U.S.*

1. Atorvastatin Calcium (generic for Lipitor)
Atorvastatin is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors

2. Levothyroxine (generic for Synthroid)
Levothyroxine treats hypothyroidism (low thyroid hormone). It is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer

3. Lisinopril (generic for Prinivil)
Lisinopril is used to treat high blood pressure (hypertension) or congestive heart failure. It is also used to improve survival after a heart attack

4. Omeprazole (generic for Prilosec)
Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid)

5. Metformin (generic for Glucophage)
Metformin is used to improve blood sugar control in people with type 2 diabetes. It is sometimes used in combination with insulin or other medications, but this medicine is not for treating type 1 diabetes

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6. Amlodipine (generic for Norvasc)
Amlodipine is used to treat high blood pressure (hypertension) or chest pain (angina) and other conditions caused by coronary artery disease. This medication is for use in adults and children who are at least 6-years-old

7. Simvastatin (generic for Zocor)
Simvastatin is used to lower cholesterol and triglycerides (types of fat) in the blood

8. Hydrocodone/Acetaminophen (generic for Lortab)
Hydrocodone and acetaminophen combination is used to relieve moderate to moderately severe pain

9. Metoprolol ER (generic for Toprol XL)
Metoprolol ER is used to treat angina (chest pain) and hypertension (high blood pressure). It is also used to treat or prevent heart attack

10. Losartan (generic for Cozaar)
Losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease

Use of prescriptions among Americans

According to the Journal of the American Medical Association (JAMA), nearly 60 percent of Americans, 20 and older, reported use of any one Rx drug. The prevalence of polypharmacy, which is the use of multiple prescriptions, was found to be about 15% of that population. The study found the number of individuals using prescription drugs for treatment has risen since the year 2000.

"More Americans are being diagnosed with these chronic illnesses every day,” said Brad Bangerter, GM of RxSaver. “While much of the national concern has been on high cost specialty drugs, medications required to treat more common conditions also have a financial impact on millions of Americans, even when they have insurance."

How can patients better afford prescription prices?

There is a national movement to educate consumers on how to better afford prescriptions. RxSaver is fighting the battle against high Rx prices, by using technology to display discounted pharmacy prices. By empowering consumers with pharmacy discount search tools, RxSaver is providing consumers with a better alternative to paying high prices for their medications, while also increasing medication adherence.

Patients can search for the lowest prices on their prescriptions through the RxSaver website or on the RxSaver app.

Top 50 Prescription Drugs Filled in the U.S.*

  1. Atorvastatin Calcium(generic of Lipitor)
  2. Levothyroxine (generic of Synthroid)
  3. Lisinopril (generic of Prinivil)
  4. Omeprazole (generic of Prilosec)
  5. Metformin (generic for Glucophage)
  6. Amlodipine (generic for Norvasc)
  7. Simvastatin (generic for Zocor)
  8. Hydrocodone/Acetaminophen (generic for Lortab)
  9. Metoprolol ER (generic for Toprol XL)
  10. Losartan (generic for Cozaar)
  11. Azithromycin (generic for Zithromax)
  12. Zolpidem (generic for Ambien)
  13. Hydrochlorothiazide (generic for Microzide)
  14. Furosemide (generic for Lasix)
  15. Metoprolol (generic for Lopressor)
  16. Pantoprazole (generic for Protonix)
  17. Gabapentin (generic for Neurontin)
  18. Amoxicillin (generic for Amoxil)
  19. Prednisone (generic for Deltasone)
  20. Sertraline (generic for Zoloft)
  21. Tamsulosin (generic for Flomax)
  22. Fluticasone (generic for Flonase)
  23. Pravastatin (generic for Pravachol)
  24. Tramadol (generic for Ultram)
  25. Montelukast (generic for Singulair)
  26. Escitalopram (generic for Lexapro)
  27. Carvedilol (generic for Coreg)
  28. Alprazolam (generic for Xanax)
  29. Warfarin (generic for Coumadin)
  30. Meloxicam (generic for Mobic)
  31. Clopidogrel (generic for Plavix)
  32. Amoxicillin/Potassium Clavulanate ER (generic for Augmentin XR)
  33. Allopurinol (generic for Zyloprim)
  34. Bupropion (generic for Wellbutrin)
  35. Lisinopril/HCTZ (generic for Zestoretic)
  36. Citalopram (generic for Celexa)
  37. Losartan Potassium (generic for Cozaar)
  38. Atenolol (generic for Tenormin)
  39. Cialis
  40. Duloxetine (Cymbalta)
  41. Fluoxetine (generic for Prozac)
  42. Fenofibrate (generic for Tricor)
  43. Crestor
  44. Venlafaxine (generic for Effexor)
  45. Ventolin
  46. Amphetamine/Dextroamphetamine (generic for Adderall)
  47. Cyclobenzaprine (generic for Flexeril)
  48. Trazodone (generic for Oleptro)
  49. Methylprednisolone (generic for Medrol)
  50. Potassium Chloride (generic for Klor-Con)

*In order to compile the Top 50 list of drugs filled, RxSaver analyzed its network of 181,661 claims, from January 1 to March 31, 2016, related to prescription drug purchases.

Detailed drug information pulled from

RxSaver Editors

RxSaver Editors

RxSaver Editors are wellness enthusiasts who help you learn how you can save the most on prescription medication costs and other health-related topics.

The information on this site is generalized and is not medical advice. It is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional. Always seek the advice of your healthcare professional with any questions you may have regarding a medical condition. Never disregard seeking advice or delay in seeking treatment because of something you have read on our site. RxSaver makes no warranty as to the accuracy, reliability or completeness of this information.

If you are in crisis or you think you may have a medical emergency, call your doctor or 911 immediately.

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Savings calculated based on the pharmacy’s cash price. On average, fourteen percent of RxSaver prescription purchases receive savings of 85% or more.

The discount coupons offered by RxSaver are intended for out-of-pocket paying consumers and may not be used with commercial health plans or any federal or state funded health care program, such as Medicare or Medicaid. Certain states have imposed restrictions on the use of prescription drug coupons and, therefore, the RxSaver coupons are void where prohibited by law. The discount coupons available through RxSaver are not a form of insurance coverage.

Prescription drug pricing fluctuates frequently. Therefore, RxSaver pricing is subject to change without notice. Nothing contained in this website, or any other RxSaver property constitutes medical advice. Please consult a medical professional for information about a specific prescription drug product.