Top 100 Most Commonly Searched Medications

Prescription Drugs

Top 100 Most Commonly Searched Medications

RxSaver Updates
RxSaver Editors
By RxSaver Editors
Aug 31, 2020
Top 100 Most Commonly Searched Medications

The RxSaver™ prescription savings platform was created to provide discount coupons that can be searched in seconds. RxSaver has saved Americans over $500 million in costs since its inception in 2017 and continues to offer significant savings on prescription medication prices.

RxSaver has helped millions find coupons for their medications and helped them save on out of pocket costs. We compiled a list of the most frequently searched prescription drugs searched on RxSaver for coupons at nearby pharmacies.

RxSaver Top Drug Searches (Based on data from June-August 2020)

1. Sildenafil is generic Viagra, and it is a vasodilator (opens blood vessels) used mainly to treat erectile dysfunction (the inability to get or keep an erection). Sildenafil may also be used to treat pulmonary hypertension (high blood pressure).

2. Eliquis is a blood thinner that works by blocking one of your clotting factors. It prevents your body from forming blood clots and reduces your risk of stroke and your chance of having a blood clot travel through your bloodstream (systemic embolism).

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3. Gabapentin is generic Neurontin, and it is an anti-seizure medication with several uses. It may be used to treat seizures, neuropathic pain (nerve pain), alcohol dependence, fibromyalgia, and pain associated with shingles.

4. Atorvastatin calcium is generic Lipitor, and it belongs to the class of drugs known as “statins.” Atorvastatin inhibits your body from making cholesterol and can lower total cholesterol, low-density lipoproteins (LDL), and triglycerides and reduce your risk of heart attack or stroke.

5. Levothyroxine sodium is a generic Synthroid. It is a synthetic thyroid hormone used to replace your body’s thyroxine (T4) when your thyroid does not produce it or when your thyroid has been surgically removed.

6. Viagra also known as sildenafil, is a vasodilator (opens blood vessels) used mainly to treat erectile dysfunction (the inability to get or keep an erection). Viagra may also be used to treat pulmonary hypertension (high blood pressure in the lungs).

7. Amoxicillin is an antibiotic related to penicillin. It is used to treat bacterial infections such as strep throat, ear infections, sinus infections, pneumonia, dental infections, Lyme disease, chlamydia, ulcers caused by Helicobacter pylori (H. pylori), and to prevent heart infections after dental procedures.

8. Adderall is a combination product containing the amphetamine salts dextroamphetamine and amphetamine. It is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy (excessive and uncontrollable daytime sleepiness) in children and adults.

9. Hydrocodone/Acetaminophen is a combination product that contains an opioid analgesic (hydrocodone) as well as a non-opioid analgesic (acetaminophen), and it is used to treat moderate to severe pain. It is classified as a narcotic drug, and it is also known as Norco, Vicodin, and Lorcet.

10. Gabapentin is generic Neurontin, and it is an anti-seizure medication with several uses. It may be used to treat seizures, neuropathic pain (nerve pain), alcohol dependence, fibromyalgia, and pain associated with shingles.

11. Lisinopril is in the category of drugs known as ACE (angiotensin-converting enzyme) inhibitors, and it is used to treat high blood pressure. Lisinopril may also be used to treat congestive heart failure (CHF) and to lower the risk of death after a myocardial infarction (heart attack), as well as to protect your kidneys if you have kidney disease or diabetes.

12. Cialis also known as tadalafil, is a vasodilator (opens blood vessels) used mainly to treat erectile dysfunction (the inability to get or keep an erection). It is also used to treat an enlarged prostate or high blood pressure in the lungs (pulmonary hypertension).

13. Tadalafil is a generic Cialis, and it is a vasodilator (opens blood vessels) used mainly to treat erectile dysfunction (the inability to get or keep an erection). It is also used to treat an enlarged prostate or high blood pressure in the lungs (pulmonary hypertension).

14. Adderall XR is the extended-release formulation of the combination product containing the amphetamine salts dextroamphetamine and amphetamine. It is used to treat attention deficit hyperactivity disorder (ADHD) in children and adults, but it is not used for narcolepsy.

15. Amlodipine besylate is a calcium channel blocker and the active ingredient in Norvasc. Amlodipine is used to treat high blood pressure and to treat or prevent angina (chest pain caused by blocked blood flow to the heart) in people with coronary artery disease (CAD).

16. Albuterol sulfate HFA is a bronchodilator (opens airways in lungs) inhaler, and brand names include ProAir HFA, Ventolin HFA, and Proventil HFA. Albuterol is used to treat bronchospasms during an asthma attack and to treat or prevent bronchospasms related to exercise.

17. Synthroid is a synthetic thyroid hormone used to replace your body’s thyroxine (T4) when your thyroid does not produce it or when your thyroid has been surgically removed. Synthroid is also known by the generic name levothyroxine.

18. Metformin HCL ER is an extended-release antidiabetic drug that decreases your body’s production of glucose and increases your body’s sensitivity to insulin. Metformin ER is used along with diet and exercise to control blood sugar in patients with type 2 diabetes, as well as to induce ovulation in women with polycystic ovary syndrome (PCOS).

19. Omeprazole is generic Prilosec, and it is in the category of drugs known as proton pump inhibitors (prevents your stomach from releasing acid). It is used to treat acid reflux as well as stomach and intestinal ulcers, and it is part of the treatment regimen used for ulcers caused by Helicobacter pylori (H. pylori) infection.

20. Phentermine Hydrochloride is a stimulant and appetite suppressor, also known as Adipex. It is used as a short-term weight loss medication in combination with exercise, diet, and behavior modifications.

21. Norco is a combination product that contains an opioid analgesic (hydrocodone) as well as the active ingredient in Tylenol (acetaminophen). Norco is classified as a narcotic drug, and it is used to treat moderate to severe pain.

22. ProAir HFA is an inhaler that contains the bronchodilator (opens airways in lungs) albuterol sulfate. ProAir is used to treat bronchospasms during an asthma attack and to treat or prevent bronchospasms related to exercise.

23. Albuterol sulfate is a bronchodilator (opens airways in the lungs), and it is the active ingredient in inhalers such as Ventolin, Proventil, and ProAir. Albuterol inhalers and the solution for nebulizers are used to treat bronchospasms during an asthma attack and to treat or prevent bronchospasms related to exercise.

24. Losartan potassium/hydrochlorothiazide is a combination drug containing the angiotensin receptor blocker (ARB) losartan and the diuretic (water pill) hydrochlorothiazide. It is used to treat high blood pressure and to prevent strokes, and brand names include Cozaar and Hyzaar.

25. Xarelto is a blood thinner that prevents your body from forming blood clots by blocking one of your clotting factors. Xarelto is used to reduce your risk of stroke and your chance of having a blood clot travel through your bloodstream (systemic embolism), as well as to treat or prevent blood clots in your veins or your lungs.

26. Metoprolol succinate ER is generic Toprol XL, and it is a long-acting beta-blocker that helps lower your heart rate. Metoprolol succinate is used to treat high blood pressure, angina (chest pain), congestive heart failure (CHF), and to prevent migraines.

27. Tramadol HCL is generic Ultram, and it is classified as a narcotic drug. It is an opioid analgesic that acts in your brain to decrease pain and is used to treat moderate to moderately severe pain.

28. Symbicort is a combination inhaler that contains the steroid budesonide and the beta-agonist (relaxes muscles in the lungs) formoterol. Symbicort is used to treat asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, and emphysema.

29. Estradiol is a hormone replacement for estrogen, and it is used to treat the symptoms of menopause and to prevent osteoporosis (porous and fragile bones) in women postmenopause. Estradiol may also be used to relieve the symptoms of advanced breast cancer or prostate cancer.

30. Percocet is a combination pain medication that contains the opioid analgesic oxycodone as well as the non-opioid analgesic acetaminophen. Percocet is classified as a narcotic drug, and it is used to treat moderate to severe pain.

31. Pantoprazole sodium is generic Protonix, and it is in the category of proton pump inhibitors (prevents your stomach from releasing acid). It is used to treat erosion of the esophagus due to acid reflux, bleeding of the stomach, and ulcers caused by Helicobacter pylori (H. pylori) infections.

32. Rosuvastatin calcium is generic Crestor, and it belongs to the class of drugs known as “statins.” Rosuvastatin inhibits your body from making cholesterol, and it is used to raise high-density lipoproteins (HDL) and lower total cholesterol, low-density lipoproteins (LDL), and triglycerides, as well as to prevent heart disease.

33. Oxycodone-acetaminophen is a combination product that contains an opioid analgesic (oxycodone) as well as the active ingredient in Tylenol (acetaminophen)—it is used to treat moderate to severe pain. It is classified as a narcotic drug, and brand names include Percocet and Endocet.

34. Alprazolam is generic Xanax, and it is a short-acting benzodiazepine. Alprazolam is used to treat generalized anxiety disorder and panic disorder (recurrent panic attacks).

35. Suboxone is an opioid dependence drug containing the opioid agonist buprenorphine and the opioid antagonist naloxone. Suboxone is used as maintenance therapy in medication-assisted treatment (MAT) for opioid use disorder.

36. Ventolin HFA is an inhaler that contains the bronchodilator (opens airways in lungs) albuterol sulfate. Ventolin is used to treat bronchospasms during an asthma attack and to treat or prevent bronchospasms related to exercise.

37. Prednisone is a steroid drug that acts as an anti-inflammatory agent in conditions of the skin, digestive system, eyes, respiratory system, and others. Prednisone is used to treat asthma, allergic reactions, certain autoimmune disorders, symptoms of certain cancers, and to suppress the immune system in organ transplants.

38. Losartan potassium/hydrochlorothiazide is a combination drug containing the angiotensin receptor blocker (ARB) losartan and the diuretic (water pill) hydrochlorothiazide. It is used to treat high blood pressure and to prevent strokes, and brand names include Cozaar and Hyzaar.

39. Cyclobenzaprine HCL is a muscle relaxant related to tricyclic antidepressants, and it is used, along with rest and physical therapy, as a short-term treatment for muscle spasms associated with musculoskeletal conditions. Cyclobenzaprine may also be used to treat fibromyalgia.

40. Sertraline is generic Zoloft, and it is an antidepressant in the category of drugs known as selective serotonin reuptake inhibitors (SSRIs). Sertraline is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, social anxiety, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

41. Januvia is an anti-diabetic drug that increases your body’s release of insulin. It is used along with diet and exercise to control blood sugar in patients with type 2 diabetes.

42. Trulicity is an injectable anti-diabetic drug that lowers blood sugar by increasing your body’s release of insulin and decreasing the release of glucagon, a hormone that stimulates your body to produce and release glucose. Trulicity is used along with diet and exercise to control blood sugar in patients with type 2 diabetes.

43. Advair Diskus is a dry-powder inhaler containing the steroid fluticasone and the beta-agonist salmeterol. It is used to treat asthma and chronic obstructive pulmonary disease (COPD).

44. Jardiance is an anti-diabetic drug that lowers your blood sugar by increasing the excretion of glucose in the urine. Jardiance is used along with diet and exercise to control blood sugar in patients with type 2 diabetes.

45. Clindamycin is an antibiotic used to treat pneumonia, pharyngitis, ear infections, skin infections, acne, anthrax, malaria, pelvic inflammatory disease (PID), and vaginal infections, and to prevent heart infections after a dental procedure. Clindamycin is available in oral forms as well as topical and vaginal formulations.

46. Vyvanse is a long-acting central nervous system (CNS) stimulant. It is used to treat attention deficit hyperactivity disorder (ADHD) in children and adults and moderate to severe binge eating disorder in adults.

47. Hydrochlorothiazide s a diuretic or “water pill” that prevents edema (swelling and water retention) by helping the kidneys move excess salt and water out of the body. It is mainly used to treat hypertension (high blood pressure) and edema caused by heart failure.

48. Colchicine is an anti-gout medication that works in many ways. Most notably, it has anti-inflammatory properties that can help reduce joint pain and swelling associated with a gout attack (also known as a gout flare). When taken long-term, colchicine can also help prevent future gout attacks.

49. Lisinopril-Hydrochlorothiazide is a combination drug containing the ACE (angiotensin-converting enzyme) inhibitor lisinopril and the diuretic (water pill) hydrochlorothiazide. It is used to treat high blood pressure, and brand names include Zestoretic and Prinzide.

50. Duloxetine HCL is is an SNRI (serotonin-norepinephrine reuptake inhibitor) antidepressant that primarily works to reduce and rebalance specific chemicals, including serotonin and norepinephrine, in the brain. Duloxetine is mainly used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD).

51. Zolpidem tartrate is generic Ambien. It is a central nervous system (CNS) depressant used as a short-term treatment for insomnia marked by difficulty falling asleep.

52. Buprenorphine is a partial opioid agonist and an opioid antagonist, and brand names include Subutex, Belbuca, and Butrans. It is used as maintenance therapy in medication-assisted treatment (MAT) for opioid use disorder, and as a treatment for moderate to severe pain.

53. Breo Ellipta is an inhaler containing the steroid fluticasone and the beta-agonist vilanterol. It is used to treat chronic obstructive pulmonary disease (COPD) and asthma.

54. Clobetasol propionate is a topical (used on the skin) steroid with anti-inflammatory and anti-itching effects. Clobetasol is used to treat skin and scalp conditions such as psoriasis and other rashes with or without inflammation.

55. Escitalopram oxalate is generic Lexapro, and it is an antidepressant in the category of drugs known as selective serotonin reuptake inhibitors (SSRIs). Escitalopram is used to treat depression and generalized anxiety disorder.

56. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). It is used to treat mild to moderate pain, inflammation, fever, arthritis, and menstrual pain and cramping.

57. Bupropion Hydrochloride ER (XL) is generic Wellbutrin XL, and it is an antidepressant in the category of norepinephrine and dopamine reuptake inhibitors (NDRIs). It is used to treat depression, seasonal affective disorder (SAD), attention deficit hyperactivity disorder (ADHD), and sometimes to aid in smoking cessation.

58. Xanax is an anti-anxiety drug containing the short-acting benzodiazepine alprazolam. Xanax is used to treat generalized anxiety and panic disorder (recurrent panic attacks).

59. Trazodone HCL Trazodone is a generic Desyrel. Although trazodone is an antidepressant (treats depression), it is used mainly to treat insomnia (difficulty sleeping).

60. Montelukast sodium is generic Singulair. It is used to treat symptoms of seasonal and year-round allergies, to treat and prevent symptoms of asthma, and to treat bronchospasms related to exercise.

61. Tretinoin is a form of vitamin A that is used topically to treat acne. Brand names for topical tretinoin include Retin-A, Renova, Atralin, and Avit.

62. Valacyclovir HCL is generic Valtrex, and it is an antiviral used to treat or suppress herpes, cold sores, chickenpox, and shingles.

63. Oxycodone HCL ER is a longer-acting opioid formulation of Oxycodone HCl that works by blocking the body’s pain signals and receptors. ER stands for “extended release,” which refers to this drug’s ability to help manage pain over a longer period of time compared to its immediate-release formulation.

64. Metformin HCL ER is an extended-release antidiabetic drug that decreases your body’s production of glucose and increases your body’s sensitivity to insulin. Metformin ER is used along with diet and exercise to control blood sugar in patients with type 2 diabetes, as well as to induce ovulation in women with polycystic ovary syndrome (PCOS).

65. Simvastatin is a generic Zocor, and it belongs in the class of drugs known as “statins.” Simvastatin inhibits your body from making cholesterol, and it is used to raise high-density lipoproteins (HDL) and lower total cholesterol, low-density lipoproteins (LDL), and triglycerides, as well as to prevent heart disease.

66. Metoprolol Tartrate is a beta-blocker that blocks epinephrine’s effect on the beta-1 receptors of the heart. It is mainly used to treat hypertension (high blood pressure) by lowering blood pressure and can also be used to treat certain types of angina (chest pain).

67. Doxycycline Hyclate is an antibiotic related to tetracycline. Doxycycline is used to treat bacterial infections, such as acne, rosacea, pneumonia, sinusitis, dental infections, anthrax, Lyme disease, malaria, infections of the digestive tract, and several sexually transmitted infections.

68. Zofran is an anti-nausea medication, also known as ondansetron. Zofran is used to prevent nausea and vomiting related to cancer treatment; nausea and vomiting due to viral or bacterial stomach infections; and postoperative nausea and vomiting.

69. Proair HFA is an inhaler that contains the bronchodilator (opens airways in lungs) albuterol sulfate. ProAir is used to treat bronchospasms during an asthma attack and to treat or prevent bronchospasms related to exercise.

70. Ozempic is the brand name for generic semaglutide, which is used to treat type 2 diabetes. Ozempic works in a number of ways: it can increase the liver’s production of insulin when the body’s blood sugar is high and can lower the amount of sugar from the liver by slowing down the movement of food from the stomach.

71. Clonazepam is generic Klonopin, and it is a long-acting benzodiazepine. Clonazepam is used to treat seizures, panic disorder, anxiety, restless leg syndrome, sleep terrors and sleepwalking, and Tourette syndrome.

72. Cephalexin is a cephalosporin antibiotic used to treat certain bacterial infections by working to stop the growth of bacteria. It can be used to treat specific strains of bacteria that may cause respiratory, ear, skin, and bladder infections.

73. Augmentin is an antibiotic related to penicillin and contains a combination of amoxicillin and clavulanic acid. Augmentin is used to treat respiratory tract infections, ear infections, sinus infections, skin infections, urinary tract infections, and diverticulitis.

74. Meloxicam is generic Mobic. It is a non-steroidal anti-inflammatory drug (NSAID), and it is used to treat arthritis.

75. Azithromycin is a generic Zithromax or Z-Pak. It is used to treat bacterial infections such as pneumonia, strep throat, sinus infections, some skin infections, and certain sexually transmitted infections.

76. Lipitor inhibits your body from making cholesterol and can lower total cholesterol, low-density lipoproteins (LDL), and triglycerides and reduce your risk of heart attack or stroke.

77. Lexapro is an antidepressant in the category of drugs known as selective serotonin reuptake inhibitors (SSRIs). Lexapro is also known by its generic name, escitalopram, and it is used to treat depression and generalized anxiety disorder.

78. Lantus is an injectable long-acting insulin with effects lasting up to twenty-four hours. Lantus is used to control blood sugar in patients with type 1 or type 2 diabetes.

79. Metronidazole is an antibiotic that can treat a wide number of bacterial infections. It is also an antiprotozoal medication that works by stopping the growth of certain parasites. Metronidazole is commonly used to treat infections of the vagina, skin, and stomach.

80. Buprenorphine HCL is a partial opioid agonist and an opioid antagonist, and brand names include Subutex, Zubsolv, and Butrans. It is used as maintenance therapy in medication-assisted treatment (MAT) for opioid use disorder, and as a treatment for moderate to severe pain.

81. Tamsulosin HCL is generic Flomax. It is used to treat benign prostatic hyperplasia (BPH), or enlarged prostate, and to help pass kidney stones.

82. Doxycycline Hyclate is an antibiotic related to tetracycline. Doxycycline is used to treat bacterial infections, such as acne, rosacea, pneumonia, sinusitis, dental infections, anthrax, Lyme disease, malaria, infections of the digestive tract, and several sexually transmitted infections.

83. Premarin is a mixture of natural estrogens obtained from pregnant mares. Premarin is used to treat symptoms of menopause, such as hot flashes and vaginal dryness and to prevent osteoporosis (fragile, porous bones) after menopause.

84. Ambien is a central nervous system (CNS) depressant used as a short-term treatment for insomnia, which is difficulty falling asleep. Ambien is also known by its generic name, zolpidem.

85. Shingrix is a vaccine used to prevent herpes zoster (shingles) in adults 50 years and older. Shingrix is given in two doses two to six months apart.

86. Trelegy Ellipta is the brand name of an inhaler composed of a combination of three generic medications in a single inhalation: fluticasone, umeclidinium, and vilanterol. Trelegy Ellipta is used for long-term treatment of COPD (chronic obstructive pulmonary disease) and can help prevent COPD flare-ups by opening your airways and reducing inflammation.

87. Armour Thyroid is a natural thyroid replacement hormone made from porcine (pig) thyroid glands. Armour Thyroid contains liothyronine (T3) and levothyroxine (T4), and it is used to replace your body’s T3 and T4 hormones when your thyroid does not produce these or when your thyroid has been surgically removed.

88. Hydroxychloroquine Sulfate is an antimalarial medication used to treat malaria. It is also an immunosuppressant (meaning it suppresses the immune system’s activity) and is an important medication in the treatment of the autoimmune disease lupus. Its immunosuppressive properties can also be used in the treatment of rheumatoid arthritis.

89. Bystolic is a beta-blocker that helps lower your heart rate and blood pressure. It is used to treat high blood pressure, which lowers your risk of stroke and heart attack.

90. Wellbutrin XL is an antidepressant in the category of norepinephrine and dopamine reuptake inhibitors (NDRIs). It is used to treat depression, seasonal affective disorder (SAD), attention deficit hyperactivity disorder (ADHD), and sometimes to aid in smoking cessation.

91. Diclofenac/Sodium is generic Voltaren, and it is a nonsteroidal anti-inflammatory drug (NSAID). Diclofenac sodium is used to treat arthritis in children and adults and post-surgery pain in children three years and older.

92. Fenofibrate is an antilipemic drug (prevents the accumulation of fatty substances in the blood). Fenofibrate works by increasing specific enzymes in the body to treat high cholesterol by helping to lower high LDL (bad cholesterol). It also treats hypertriglyceridemia by lowering high triglycerides (fat found in the blood) and is typically prescribed together with a low-fat diet.

93. Pregabalin is believed to work by reducing electric signals sent out by damaged or overactive nerves in the body. It is most commonly prescribed to treat neuropathic pain and fibromyalgia, but can also be used as an anticonvulsant to treat certain types of seizures.

94. Vitamin D is a fat-soluble vitamin. It is a dietary supplement used to treat Vitamin D deficiency in those with low levels of Vitamin D. In patients with osteoporosis, Vitamin D can also be taken with calcium to help improve calcium absorption in the body.

95. Pravastatin sodium is generic Pravachol, and it belongs to the class of drugs known as “statins.” Pravastatin inhibits your body from making cholesterol, and it is used along with diet to raise your good cholesterol (HDL) and lower your bad cholesterol (LDL and triglycerides) as well as to reduce your risk of heart attack or stroke.

96. Lyrica is an anti-seizure medication similar to gabapentin. It is used to treat fibromyalgia, nerve pain associated with diabetes, pain associated with shingles, and seizures.

97. Testosterone Cypionate is an anabolic steroid hormone used to treat low testosterone levels in men. It is used to treat hypogonadism and delayed puberty in males and is also prescribed for hormone replacement therapy in transgender men (female to male).

98. Buprenorphine HCL is a partial opioid agonist and an opioid antagonist, and brand names include Subutex, Zubsolv, and Butrans. It is used as maintenance therapy in medication-assisted treatment (MAT) for opioid use disorder, and as a treatment for moderate to severe pain.

99. Myrbetriq the brand name for generic mirabegron, works by relaxing the bladder muscles, preventing bladder contraction and the urgency to urinate. Myrbetriq is used to treat overactive bladder (OAB) by increasing the bladder’s ability to store urine.

100. Finasteride blocks a chemical reaction in the body that creates a hormone which can cause hair loss and prostate growth in males. It is used to treat male pattern hair loss (androgenetic alopecia) and benign prostate hyperplasia (BPH).

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RxSaver Editors

RxSaver Editors

RxSaver Editors are wellness enthusiasts who help you learn how you can save the most on prescription medication costs and other health-related topics.

The information on this site is generalized and is not medical advice. It is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional. Always seek the advice of your healthcare professional with any questions you may have regarding a medical condition. Never disregard seeking advice or delay in seeking treatment because of something you have read on our site. RxSaver makes no warranty as to the accuracy, reliability or completeness of this information.

If you are in crisis or you think you may have a medical emergency, call your doctor or 911 immediately.

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