The Cost of Estradiol Without Insurance

Prescription Drugs

The Cost of Estradiol Without Insurance

Jennifer Hadley
By Jennifer Hadley
Nov 18, 2020 - Updated Jan 13, 2021
Carina Fung, PharmD, BCPPS
Medically Reviewed ByCarina Fung, PharmD, BCPPS
an estradiol bottle with estradiol pills coming out

As one of three estrogen hormones produced in the body, estradiol plays a crucial role in the health of women. Since the production of estradiol declines in menopause, adding estradiol in the form of a tablet, patch, or vaginal cream, can help to minimize symptoms of menopause, including bone loss. It is a generic medication, making the cost of estradiol without insurance less expensive than a brand name drug.

Save On Estradiol Now

Free Coupon. No Insurance Needed.

Find Lowest Price
Illustration of an estradiol bottle

How much does estradiol cost without insurance?

The cost of estradiol without insurance starts at $7.01 for 1mg and 30 tablets using an RxSaver coupon.

RxSaver offers coupons for several forms of estradiol, helping to ensure the medication is affordable. Pharmacy coupon prices vary by location and pharmacy, so be sure to use RxSaver to check pricing at your local pharmacies.

Get Free Coupons on Your Prescription Medications

What is estradiol?

Estradiol is a female hormone that is naturally produced by the body. In women who are actively menstruating, estradiol is produced in the ovaries and plays a role in triggering ovulation. During pregnancy, it is suspected to play a vital role in maintaining pregnancy. Estradiol is also important for maintaining bone health. As women enter perimenopause and then menopause estradiol production declines substantially.

What conditions does estradiol treat?

Estradiol is used to treat symptoms of menopause and may be used to prevent bone loss (osteoporosis) in postmenopausal women.

Common Symptoms of Menopause

Some women experience no symptoms of menopause, while others may experience mild symptoms. Other women may struggle with severe symptoms of menopause. Symptoms of menopause may include:

  • Anxiety
  • Chills
  • Decreased sex drive
  • Depression
  • Dry skin
  • Difficulty concentrating
  • Difficulty sleeping
  • Forgetfulness
  • Hair thinning
  • Headaches
  • Hot flashes
  • Irregular or missed periods
  • Loss of fullness of breasts
  • Mood changes
  • Night sweats
  • Pain during sexual intercourse
  • Reduced muscle mass
  • Stiff joints
  • Skin flushing
  • Vaginal dryness
  • Weight gain

Common Symptoms of Osteoporosis

Osteoporosis often progresses with no signs or symptoms. However, there is a direct correlation between declining estrogen production and osteoporosis. Women who experience premature or early menopause may be particularly vulnerable to osteoporosis. Common symptoms of osteoporosis include:

  • Sudden fracture of a bone
  • Sudden collapse of vertebrae
  • Loss of height
  • Severe back pain
  • Stooped posture

How does estradiol work?

Estradiol medication works in the same way that the naturally occurring estradiol hormone works. It replaces lost estrogen, which helps to reduce symptoms of menopause and may be used to support bone health as women age. It is either taken orally as a tablet or absorbed through the skin (vaginal creams, skin patches).

Common Side Effects of Estradiol

Like all prescription medications, estradiol has the potential to cause mild to severe side effects. Some side effects may resolve on their own, as your body adapts to the medication. Other side effects may be so severe that your health care provider will recommend a change in medication. A list of possible side effects of estradiol includes:

  • Nausea
  • Bloating
  • Breast tenderness
  • Headache
  • Weight gain
  • Diarrhea
  • Mood changes
  • Breakthrough bleeding

Severe side effects of estradiol are rare but have been reported. Notify your health care provider immediately if you notice any of the following:

  • Chest pain
  • Numbness or weakness on one side of the body
  • Sudden vision loss
  • Jaundice
  • Pelvic pain
  • Lump in your breast
  • Swelling

Can you buy estradiol over the counter?

Estradiol is not available over the counter in the United States. You will need a prescription from a health care provider. Estradiol must be purchased through a pharmacy.

"Your app saved me $60 on a medication for my dog! You all rock!"


Download In The Apple App Store
Download In The Google Play Store
Download Our Mobile App

Always CheckRxSaver Before Filling a Prescription

Before filling a prescription for estradiol, or thousands of other medications, be sure to check RxSaver. RxSaver is a free prescription drug platform offering savings of up to 85% on brand name and generic medications. RxSaver is designed to be used without insurance, or in place of your insurance if the coupon price beats your insurance copay.

Estradiol: 1 mg / 30 tablets

*Lowest online price at national pharmacy chains Costco, CVS, RiteAid, Walgreens and Walmart as of 1/13/2021. Prices vary by location and pharmacy, see for actual pricing in your area.

Jennifer Hadley

Jennifer Hadley

Jen Hadley is a freelance writer and journalist based in Los Angeles, who writes extensively about the medical, legal, health care, and consumer products industries. Jen is a regular contributor to RxSaver.

Carina Fung, PharmD, BCPPS

Carina Fung, PharmD, BCPPS

Carina Fung, PharmD, BCPPS., is a pharmacist who earned her PharmD from St. John’s University in Queens, NY. She maintains an active practice, serving as a Board-Certified Pediatric Pharmacotherapy Specialist at a large metropolitan teaching hospital in New York City. Carina has also published in pharmacy journals and works as a consultant reviewing medical articles for publication.

The information on this site is generalized and is not medical advice. It is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional. Always seek the advice of your healthcare professional with any questions you may have regarding a medical condition. Never disregard seeking advice or delay in seeking treatment because of something you have read on our site. RxSaver makes no warranty as to the accuracy, reliability or completeness of this information.

If you are in crisis or you think you may have a medical emergency, call your doctor or 911 immediately.

Download In The Apple App Store
Download In The Google Play Store
LegitScript approved

Copyright © RxSaver. All rights reserved.

Savings calculated based on the pharmacy’s cash price. On average, fourteen percent of RxSaver prescription purchases receive savings of 85% or more.

The discount coupons offered by RxSaver are intended for out-of-pocket paying consumers and may not be used with commercial health plans or any federal or state funded health care program, such as Medicare or Medicaid. Certain states have imposed restrictions on the use of prescription drug coupons and, therefore, the RxSaver coupons are void where prohibited by law. The discount coupons available through RxSaver are not a form of insurance coverage.

Prescription drug pricing fluctuates frequently. Therefore, RxSaver pricing is subject to change without notice. Nothing contained in this website, or any other RxSaver property constitutes medical advice. Please consult a medical professional for information about a specific prescription drug product.

Trademarks other than RxSaver’s are the property of their respective owners. Presence of a third-party trademark does not mean that RxSaver has any relationship with that third party or that such third party endorses or sponsors RxSaver.