10 Common Side Effects of Eliquis

Prescription Drugs

10 Common Side Effects of Eliquis

Jennifer Hadley
By Jennifer Hadley
Mar 15, 2021
Carina Fung, PharmD, BCPPS
Medically Reviewed ByCarina Fung, PharmD, BCPPS
Woman holding a bottle of Eliquis

All prescription medications have possible side effects. However, your health care provider will only prescribe medication if they determine that the benefits of the medication outweigh the possible risks.

The popular blood thinner, Eliquis, is no exception. It is a very effective medication, used to prevent blood clots, but does pose the risk of side effects.

Here are 10 common side effects of Eliquis.

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Most Common Side Effects of Eliquis

Because Eliquis is used to prevent blood clots from forming, it is commonly referred to as a blood thinner. As such, the most common side effects of Eliquis include:

  • Bleeding
  • Bruising more easily than normal
  • Anemia

Other common side effects of Eliquis may include:

  • Allergic reaction (skin rash, itching, flushing)
  • Fatigue
  • Nausea
  • Headaches
  • Dizziness
  • Joint pain
  • Muscle weakness

The overwhelming majority of individuals who experience side effects of Eliquis will experience mild side effects. However, serious side effects may occur. Notify your health care provider of all side effects, but seek emergency treatment if you experience:

  • Chest pain
  • Changes in balance
  • Blood in stool
  • Bleeding gums
  • Coughing up blood
  • Weakness on one side of the body
  • Signs of anaphylaxis (difficulty swallowing, rapid heartbeat, swelling in the mouth, eyes)

How to Manage Side Effects of Eliquis

Do not stop taking Eliquis without speaking to your health care provider.

Abruptly stopping this medication increases your risk of stroke. If you experience painful or disruptive side effects from Eliquis, contact your health care provider immediately. They will work to find a suitable alternative to Eliquis. There are many different types of anticoagulants available that may work as potential substitutes.

Are there foods to avoid when taking Eliquis?

Unlike other blood thinners, such as Warfarin, people taking Eliquis do not need to monitor their Vitamin K intake. Grapefruit and grapefruit juice do interact with a variety of medications, including Eliqius. Grapefruit juice may increase the amount of Eliquis in your body, so it is important to exercise caution and talk with your health care provider or your pharmacist if grapefruit is part of your diet.

Can Eliquis cause depression?

Eliquis has not been conclusively linked to depression. If you begin to experience signs of depression after beginning Eliquis, talk with your health care provider immediately. Do not stop taking Eliquis before speaking with your doctor.

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Always Talk to Your Health Care Provider

If you have any side effects after beginning Eliquis, contact your health care provider. But do not stop taking the medication, and do not let your prescription run out. The risk of stroke is increased if you abruptly stop taking Eliquis.

Jennifer Hadley

Jennifer Hadley

Jen Hadley is a freelance writer and journalist based in Los Angeles, who writes extensively about the medical, legal, health care, and consumer products industries. Jen is a regular contributor to RxSaver.

Carina Fung, PharmD, BCPPS

Carina Fung, PharmD, BCPPS

Carina Fung, PharmD, BCPPS., is a pharmacist who earned her PharmD from St. John’s University in Queens, NY. She maintains an active practice, serving as a Board-Certified Pediatric Pharmacotherapy Specialist at a large metropolitan teaching hospital in New York City. Carina has also published in pharmacy journals and works as a consultant reviewing medical articles for publication.

The information on this site is generalized and is not medical advice. It is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional. Always seek the advice of your healthcare professional with any questions you may have regarding a medical condition. Never disregard seeking advice or delay in seeking treatment because of something you have read on our site. RxSaver makes no warranty as to the accuracy, reliability or completeness of this information.

If you are in crisis or you think you may have a medical emergency, call your doctor or 911 immediately.