Truvada

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Truvada Side Effects

Diarrhea, headache, dizziness, trouble sleeping, back pain, or change in the color of skin on your palms or soles of your feet may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

As your immune system gets stronger with HIV treatment, it can begin to fight off infections you already had, possibly causing disease symptoms to come back. You could also have symptoms if your immune system becomes overactive. This reaction may happen at any time (soon after starting HIV treatment or many months later). Get medical help right away if you have any serious symptoms, including: unexplained weight loss, severe tiredness, muscle aches/weakness that doesn't go away, headaches that are severe or don't go away, joint pain, numbness/tingling of the hands/feet/arms/legs, vision changes, signs of infection (such as fever, chills, swollen lymph nodes, trouble breathing, cough, non-healing skin sores), signs of an overactive thyroid (such as irritability, nervousness, heat intolerance, fast/pounding/irregular heartbeat, bulging eyes, unusual growth in the neck/thyroid known as a goiter), signs of a certain nerve problem known as Guillain-Barre syndrome (such as trouble breathing/swallowing/moving your eyes, drooping face, paralysis, trouble speaking).

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression, anxiety), signs of kidney problems (such as change in the amount of urine, pink/bloody urine).

Rarely, this medication can cause severe (sometimes fatal) liver and blood problems (lactic acidosis). Tell your doctor right away if you develop symptoms of liver problems (such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine) or lactic acidosis (such as deep/rapid breathing, drowsiness, nausea/vomiting, unusual weakness).

Tenofovir may increase the risk of bone loss. Discuss the risks and benefits of treatment with your doctor, as well as the possible use of calcium and vitamin D to reduce this side effect. If you are at risk for bone loss, your doctor may monitor your bone mineral density. Tell your doctor right away if any of the following serious side effects occur: bone pain, easily broken bones.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • osteomalacia
  • hypophosphatemia
  • lactic acidosis
  • hypokalemia
  • Fanconi syndrome
  • depression
  • peripheral neuropathy
  • myopathy
  • pharyngitis
  • rhinitis
  • sinusitis
  • pneumonia
  • dyspepsia
  • steatosis of liver
  • drug-induced hepatitis
  • acute pancreatitis
  • acute renal failure
  • renal tubular necrosis
  • renal failure
  • kidney disease with reduction in glomerular filtration rate (GFR)
  • bullous dermatitis
  • pruritus of skin
  • urticaria
  • dyschromia
  • arthralgia
  • back pain
  • rhabdomyolysis
  • muscle weakness
  • myalgia
  • osteopenia
  • dizziness
  • insomnia
  • fever
  • fatigue
  • hyperhidrosis
  • pain
  • skin rash
  • weight loss
  • headache disorder
  • dyspnea
  • cough
  • nausea
  • vomiting
  • diarrhea
  • abnormal hepatic function tests
  • angioedema
  • paresthesia
  • general weakness
  • acute abdominal pain
  • maculopapular rash
  • dream disorder
  • lipodystrophy associated with human immunodeficiency virus infection
  • symptoms of anxiety

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: adefovir, orlistat, other drugs that may harm the kidneys (including aminoglycosides such as amikacin/gentamicin).

Tenofovir can decrease the effectiveness of another medication, atazanavir (by decreasing blood levels). If you are taking atazanavir with this product, you may need to also take another medication (ritonavir). Consult your doctor or pharmacist for more details.

Check the labels on all your medicines for HIV infection because they may contain the same or similar ingredients as those in this product (such as tenofovir, emtricitabine, lamivudine). Do not take medications that contain the same or similar ingredients as this product.