Spironolactone / Hydrochlorothiazide

generic for Aldactazide

Spironolactone / Hydrochlorothiazide Side Effects

Dizziness, drowsiness, lightheadedness, loss of appetite, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This product may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor right away if you have any of these serious symptoms of dehydration or mineral loss: very dry mouth, extreme thirst, muscle cramps, weakness, vomiting, fast heartbeat, severe dizziness, confusion, fainting, seizures.

This product may rarely cause high potassium levels (hyperkalemia). This can lead to serious (rarely fatal) heart rhythm problems. Tell your doctor right away if you develop any symptoms of high potassium levels, including muscle weakness, slow/irregular heartbeat, numb/tingling skin.

Tell your doctor right away if you have any serious side effects, including: joint pain, breast pain, breast enlargement in men (gynecomastia), easy bruising/bleeding, signs of kidney problems (such as change in the amount of urine), yellowing eyes/skin, dark urine, severe stomach/abdominal pain, decrease in vision, eye pain.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • hyperparathyroidism
  • hypercholesterolemia
  • hypertriglyceridemia
  • gout
  • hypomagnesemia
  • hypercalcemia
  • hyponatremia
  • hypokalemia
  • hemolytic anemia
  • aplastic anemia
  • purpura
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • neutropenic disorder
  • abnormal sexual function
  • myopia
  • xanthopsia
  • blurred vision
  • hypersensitivity angiitis
  • vasculitis
  • orthostatic hypotension
  • hypotension
  • interstitial pneumonitis
  • sialoadenitis
  • gastrointestinal irritation
  • constipation
  • hepatitis
  • obstructive hyperbilirubinemia
  • acute pancreatitis
  • interstitial nephritis
  • kidney disease with reduction in glomerular filtration rate (GFR)
  • erectile dysfunction
  • erythema multiforme
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • urticaria
  • systemic lupus erythematosus
  • muscle spasm
  • vertigo
  • dizziness
  • fever
  • fatigue
  • skin rash
  • anorexia
  • headache disorder
  • nausea
  • vomiting
  • diarrhea
  • abdominal pain with cramps
  • hyperuricemia
  • hyperglycemia
  • nervousness
  • anaphylaxis
  • secondary angle-closure glaucoma
  • paresthesia
  • general weakness
  • basal cell carcinoma of skin
  • jaundice
  • hypochloremic alkalosis
  • squamous cell carcinoma of skin
  • hypomagnesemia
  • hypocalcemia
  • hyponatremia
  • dehydration
  • hyperkalemia
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • neutropenic disorder
  • eosinophilia
  • acute confusion
  • abnormal sexual function
  • libido changes
  • hypersensitivity angiitis
  • vasculitis
  • hypotension
  • gastric ulcer
  • gastritis
  • gastrointestinal irritation
  • gastrointestinal hemorrhage
  • kidney disease with reduction in glomerular filtration rate (GFR)
  • erectile dysfunction
  • gynecomastia
  • mastalgia
  • amenorrhea
  • irregular menstrual periods
  • menstrual disorder
  • allergic dermatitis
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • pruritus of skin
  • alopecia
  • urticaria
  • cramps in legs
  • drowsy
  • dizziness
  • fever
  • ataxia

Drug Interactions

See also How to Use and Precautions sections.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: cisapride, dofetilide, lithium, other products that may affect potassium levels (such as eplerenone, tacrolimus, cyclosporine, birth control pills containing drospirenone, other diuretics like amiloride/triamterene, ACE inhibitors like benazepril/captopril, angiotensin receptor antagonists like losartan/valsartan).

Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

This medication may interfere with certain laboratory tests (including parathyroid test, protein-bound iodide test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.