Saxenda Side Effects

See also Warning section.

Nausea, vomiting, stomach upset, diarrhea, gas, heartburn, or constipation may occur. Nausea usually lessens as you continue to use liraglutide. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Persistent vomiting/diarrhea may result in a serious loss of body water (dehydration). Contact your doctor promptly if you notice any symptoms of dehydration, such as unusual dry mouth/thirst or dizziness/lightheadedness.

Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine), yellowing eyes/skin, fast heartbeat, mental/mood changes (such as depression, thoughts of suicide), signs of low blood sugar (sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet).

Get medical help right away if you have any very serious side effects, including: signs of pancreatitis or gallbladder disease (such as persistent nausea/vomiting, severe stomach/abdominal pain).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • colorectal cancer
  • hypoglycemic disorder
  • dehydration
  • body fluid retention
  • suicidal ideation
  • depression
  • atrioventricular block
  • bundle branch block
  • heart block
  • orthostatic hypotension
  • hypotension
  • pharyngitis
  • upper respiratory infection
  • xerostomia
  • gastroesophageal reflux disease
  • dyspepsia
  • constipation
  • hepatitis
  • biliary calculus
  • cholecystitis
  • cholestasis
  • acute pancreatitis
  • acute renal failure
  • kidney disease with reduction in glomerular filtration rate (GFR)
  • pruritus of skin
  • urticaria
  • back pain
  • dizziness
  • insomnia
  • fatigue
  • skin rash
  • hyperbilirubinemia
  • anorexia
  • weight loss
  • headache disorder
  • nausea
  • vomiting
  • flatulence
  • eructation
  • diarrhea
  • abdominal distension
  • abnormal hepatic function tests
  • anaphylaxis
  • angioedema
  • hypersensitivity drug reaction
  • injection site sequelae
  • general weakness
  • malaise
  • acute abdominal pain
  • necrotizing pancreatitis
  • medullary thyroid carcinoma
  • elevated serum lipase
  • elevated serum amylase
  • symptoms of anxiety
  • papillary thyroid carcinoma
  • tachycardia

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: diabetes medications (such as insulin, sulfonylureas including glyburide).

Do not use this medication with any other product that contains liraglutide or other medications which are similar to this medication, but used for diabetes (such as exenatide, dulaglutide).