Rizatriptan

generic for Maxalt

Rizatriptan Side Effects

Flushing, feelings of tingling/numbness/prickling/heat, tiredness, weakness, drowsiness, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: blue fingers/toes/nails, cold hands/feet, hearing changes, mental/mood changes.

Rizatriptan can commonly cause chest/jaw/neck tightness, pain, or pressure that is usually not serious. However, these side effects are like symptoms of a heart attack, which may include chest/jaw/left arm pain, shortness of breath, or unusual sweating. Get medical help right away if these or other serious side effects occur, including: fast/irregular heartbeat, fainting, severe stomach/abdominal pain, bloody diarrhea, signs of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision changes, confusion).

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • acute confusion
  • agitation
  • euphoria
  • depression
  • serotonin syndrome
  • blurred vision
  • dry eye
  • periorbital edema
  • ocular irritation
  • tinnitus
  • hearing loss
  • hypertension
  • acute myocardial infarction
  • angina
  • bradycardia
  • cardiac arrhythmia
  • ventricular arrhythmias
  • subarachnoid intracranial hemorrhage
  • intracerebral hemorrhage
  • cerebrovascular accident
  • xerostomia
  • dyspepsia
  • constipation
  • toxic epidermal necrolysis
  • erythema
  • pruritus of skin
  • urticaria
  • arthralgia
  • neck stiffness
  • muscle spasm
  • muscle rigidity
  • myalgia
  • drowsy
  • memory impairment
  • hallucinations
  • syncope
  • vertigo
  • dizziness
  • fatigue
  • hyperhidrosis
  • pain
  • chills
  • tremor
  • dysgeusia
  • gait abnormality
  • ataxia
  • hypesthesia
  • skin rash
  • edema
  • facial edema
  • flushing
  • polydipsia
  • tongue swelling
  • palpitations
  • wheezing
  • dyspnea
  • chest pain
  • chest tightness
  • nausea
  • vomiting
  • dysphagia
  • flatulence
  • diarrhea
  • polyuria
  • anaphylaxis
  • angioedema
  • hypersensitivity drug reaction
  • paresthesia
  • general weakness
  • irritability
  • acute abdominal pain
  • sensation of cold
  • sensation of warmth
  • disturbance of attention
  • symptoms of anxiety
  • medication overuse headache
  • drug-induced hot flash
  • tachycardia

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Do not take any MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

If you also take any ergotamine medication (such as dihydroergotamine) or other "triptan" drugs (such as sumatriptan, zolmitriptan), you will need to separate your rizatriptan dose at least 24 hours apart from your dose of these other medications to lessen the chance of serious side effects.