Quetiapine fumarate

generic for Seroquel

Quetiapine fumarate Side Effects

See also Warning section.

Constipation, drowsiness, upset stomach, tiredness, weight gain, blurred vision, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor promptly.

Dizziness or lightheadedness may occur, especially when you first start or increase your dose of this drug. Dizziness and lightheadedness can increase the risk of falling. Get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: restlessness/constant need to move, shakiness (tremor), mental/mood changes (such as increased anxiety, depression, thoughts of suicide), difficulty swallowing, constipation with persistent abdominal pain, persistent nausea/vomiting, loss of appetite, yellowing eyes/skin, interrupted breathing during sleep, trouble urinating.

Get medical help right away if you have any very serious side effects, including: fainting, seizure, severe dizziness.

This medication may rarely make your blood sugar rise, which can cause or worsen diabetes. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This drug may also cause significant weight gain and a rise in your blood cholesterol (or triglyceride) levels. These effects, along with diabetes, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor. (See also Notes section.)

Quetiapine may rarely cause a condition known as tardive dyskinesia. In some cases, this condition may be permanent. Tell your doctor right away if you develop any unusual/uncontrolled movements (especially of the face, lips, mouth, tongue, arms or legs).

This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, signs of kidney problems (such as change in the amount of urine).

Quetiapine may increase a certain natural substance (prolactin) made by your body. For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor right away.

Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • hypothyroidism
  • diabetic ketoacidosis
  • diabetes mellitus
  • hyperprolactinemia
  • SIADH syndrome
  • hypercholesterolemia
  • hypertriglyceridemia
  • hyponatremia
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • neutropenic disorder
  • eosinophilia
  • suicidal ideation
  • nightmares
  • agitation
  • depression
  • parkinsonism
  • tardive dyskinesia
  • extrapyramidal disease
  • neuroleptic malignant syndrome
  • cataracts
  • amblyopia
  • visual changes
  • hypertension
  • cardiomyopathy
  • bradycardia
  • prolonged QT interval
  • myocarditis
  • cerebrovascular accident
  • cerebral ischemia
  • thrombotic thrombocytopenic purpura
  • orthostatic hypotension
  • hypotension
  • vasodilation of blood vessels
  • pharyngitis
  • rhinitis
  • nasal congestion
  • xerostomia
  • dyspepsia
  • gastroenteritis
  • ileus
  • gastrointestinal obstruction
  • constipation
  • hepatic necrosis
  • hepatic failure
  • hepatitis
  • priapism
  • galactorrhea not associated with childbirth
  • menstrual disorder
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • hypertonia
  • rhabdomyolysis
  • myalgia
  • drowsy
  • memory impairment
  • syncope
  • seizure disorder
  • dizziness
  • insomnia
  • sleep apnea
  • fever
  • flu-like symptoms
  • hyperhidrosis
  • pain
  • tremor
  • akathisia
  • skin rash
  • peripheral edema
  • anorexia
  • weight gain
  • increased appetite
  • headache disorder
  • dysarthria
  • palpitations
  • dyspnea
  • cough
  • vomiting
  • dysphagia
  • urinary retention
  • nocturnal enuresis
  • hyperglycemia
  • abnormal hepatic function tests
  • hypothermia
  • anaphylaxis
  • lethargy
  • general weakness
  • accidental fall
  • restless leg syndrome
  • esophageal dysmotility
  • acute abdominal pain
  • pancreatitis
  • complex sleep behavior
  • dream disorder
  • acquired dystonia
  • sleep walking disorder
  • acute generalized exanthematous pustulosis
  • DRESS syndrome
  • tachycardia

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Many drugs besides quetiapine may affect the heart rhythm (QT prolongation), including amiodarone, moxifloxacin, procainamide, quinidine, sotalol, thioridazine, among others.

Other medications can affect the removal of quetiapine from your body, which may affect how quetiapine works. Examples include azole antifungals (such as itraconazole, ketoconazole), rifamycins (such as rifampin), drugs used to treat seizures (such as phenytoin), among others.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This medication may interfere with certain laboratory tests (including urine tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.