PROTONIX

brand

PROTONIX Side Effects

Headache or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: symptoms of a low magnesium blood level (such as unusually fast/slow/irregular heartbeat, persistent muscle spasms, seizures), signs of lupus (such as rash on nose and cheeks, new or worsening joint pain).

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of bacteria. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, fever, blood/mucus in your stool.

Rarely, proton pump inhibitors (such as pantoprazole) have caused vitamin B-12 deficiency. The risk is increased if they are taken every day for a long time (3 years or longer). Tell your doctor right away if you develop symptoms of vitamin B-12 deficiency (such as unusual weakness, sore tongue, or numbness/tingling of the hands/feet).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, signs of kidney problems (such as change in the amount of urine).

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • Clostridioides difficile infection
  • vitamin B12 deficiency
  • hypertriglyceridemia
  • hypomagnesemia
  • hyponatremia
  • pancytopenia
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • neutropenic disorder
  • acute confusion
  • depression
  • blurred vision
  • upper respiratory infection
  • rhinitis
  • bronchospastic pulmonary disease
  • xerostomia
  • constipation
  • acute hepatic failure
  • hepatitis
  • interstitial nephritis
  • skin photosensitivity
  • erythema multiforme
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • subacute cutaneous lupus erythematosus
  • exfoliative dermatitis
  • pruritus of skin
  • urticaria
  • arthralgia
  • rhabdomyolysis
  • myalgia
  • drowsy
  • hallucinations
  • vertigo
  • dizziness
  • insomnia
  • fatigue
  • dysgeusia
  • skin rash
  • facial edema
  • headache disorder
  • nausea
  • vomiting
  • flatulence
  • diarrhea
  • increased urinary frequency
  • abdominal pain with cramps
  • abnormal hepatic function tests
  • fracture
  • anaphylaxis
  • angioedema
  • general weakness
  • malaise
  • jaundice
  • atrophic gastritis
  • benign fundic gland polyposis of stomach
  • loss of taste

Drug Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: methotrexate (especially high-dose treatment).

Some products need stomach acid so that the body can absorb them properly. Pantoprazole decreases stomach acid, so it may change how well these products work. Some affected products include ampicillin, atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others.

This medication may interfere with certain laboratory tests (including urine test for tetrahydrocannabinol-THC, blood test to find certain tumors), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.