Prednisone Side Effects

Nausea, vomiting, loss of appetite, heartburn, trouble sleeping, increased sweating, or acne may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: muscle pain/cramps, irregular heartbeat, weakness, swelling hands/ankles/feet, unusual weight gain, signs of infection (such as fever, persistent sore throat), vision problems (such as blurred vision), symptoms of stomach/intestinal bleeding (such as stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds), mental/mood changes (such as depression, mood swings, agitation), slow wound healing, thinning skin, bone pain, menstrual period changes, puffy face, seizures, easy bruising/bleeding.

This medication may rarely make your blood sugar rise, which can cause or worsen diabetes. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

A very serious allergic reaction to this product is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • infection
  • Kaposi's sarcoma
  • pheochromocytoma
  • hyperthyroidism
  • hypothyroidism
  • diabetes mellitus
  • hypothalamic-pituitary insufficiency
  • hypercortisolism
  • hypocalcemia
  • hypernatremia
  • body fluid retention
  • hypokalemia
  • anemia
  • purpura
  • leukocytosis
  • drug-induced psychosis
  • acute confusion
  • mood changes
  • paranoid disorder
  • excitement
  • personality disorders
  • euphoria
  • depression
  • idiopathic intracranial hypertension
  • myopathy
  • ocular hypertension
  • glaucoma
  • cataracts
  • blurred vision
  • papilledema
  • hypertension
  • cardiac arrest
  • bradycardia
  • cardiac arrhythmia
  • chronic heart failure
  • thromboembolic disorder
  • vasculitis
  • telangiectasia
  • thrombophlebitis
  • ecchymosis
  • pulmonary edema
  • esophageal ulcer
  • peptic ulcer
  • gastric acid hypersecretory conditions
  • acute pancreatitis
  • gastrointestinal hemorrhage
  • amenorrhea
  • irregular menstrual periods
  • menstrual disorder
  • allergic dermatitis
  • erythema
  • skin striae
  • skin atrophy
  • hirsutism
  • acne vulgaris
  • dry skin
  • urticaria
  • lupus-like syndrome
  • arthralgia
  • tendon rupture
  • muscle weakness
  • osteoporosis
  • delirium
  • memory impairment
  • hallucinations
  • syncope
  • seizure disorder
  • vertigo
  • dizziness
  • insomnia
  • hyperhidrosis
  • skin rash
  • edema
  • facial edema
  • petechiae
  • skin scaling
  • weight gain
  • increased appetite
  • headache disorder
  • dyspnea
  • hiccups
  • nausea
  • hepatomegaly
  • abdominal distension
  • hyperglycemia
  • glycosuria
  • abnormal hepatic function tests
  • nervousness
  • fracture
  • impaired wound healing
  • anaphylaxis
  • angioedema
  • paresthesia
  • malaise
  • gastrointestinal perforation
  • lipodystrophy
  • avascular necrosis of bone
  • fat embolism
  • central serous chorioretinopathy
  • epidural lipomatosis

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aldesleukin, mifepristone, drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as dabigatran/warfarin, NSAIDs such as aspirin/celecoxib/ibuprofen).

If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (including skin tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.