Pioglitazone / Metformin

generic for Actoplus Met

Pioglitazone / Metformin Warnings

Pioglitazone may rarely cause or worsen a certain heart problem (heart failure). Tell your doctor right away if you notice any symptoms of heart failure, including: shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain.

This medication is not recommended for people with certain types of heart failure. Before using this medication, tell your doctor if you have heart failure.

Rarely, too much metformin can build up in the body and cause a serious (sometimes fatal) condition called lactic acidosis. Lactic acidosis is more likely if you are an older adult, if you have kidney or liver disease, dehydration, heart failure, heavy alcohol use, if you have surgery, if you have X-ray or scanning procedures that use iodinated contrast, or if you are using certain drugs. For some conditions, your doctor may tell you to stop taking this medication for a short time. Ask your doctor or pharmacist for more details.

Stop taking this medication and get medical help right away if you have any symptoms of lactic acidosis, such as unusual tiredness, dizziness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea.
  • Take with food.
  • If you drink alcohol, discuss the safe use of alcohol while using this medication with your healthcare professional.
  • It is very important that you take or use this exactly as directed. Do not skip doses or discontinue unless directed by your doctor.
  • Read the boxed warning information for this medication.

Lactation Warnings

  • NO KNOWN INFANT ADVERSE OUTCOMES; MFR ADVISES CAUTION
  • INSUFFICIENT DATA AVAILABLE; ALTERNATIVE AGENTS MAY BE PREFERRED

Pregnancy Warnings

  • Insufficient human data available. Insufficient animal data available. Consider maternal treatment benefits versus potential fetal/neonatal adverse outcomes. Poorly controlled maternal diabetes can lead to increased maternal and fetal/neonatal morbidity and mortality.
  • Insufficient human data available. Poorly controlled maternal diabetes can lead to increased maternal and fetal/neonatal morbidity and mortality.