Orencia Side Effects

See also How to Use section.

Headache, nausea, or cold symptoms such as stuffy head/nose may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Because abatacept works by weakening the immune system, it may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn't go away, fever, chills, cough).

Rarely, patients using abatacept have developed cancer (such as lymphoma, lung/skin cancer). Tell your doctor right away if you develop symptoms such as unusual lumps/growths/skin changes, swollen glands, night sweats, unexplained weight loss, shortness of breath, wheezing.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • bacterial sepsis
  • herpes zoster
  • herpes simplex infection
  • infection
  • malignancy
  • hypertension
  • hypersensitivity angiitis
  • cutaneous vasculitis
  • hypotension
  • pharyngitis
  • upper respiratory infection
  • rhinitis
  • sinusitis
  • pneumonia
  • influenza
  • bronchitis
  • dyspepsia
  • diverticulitis of gastrointestinal tract
  • pyelonephritis
  • urinary tract infection
  • pruritus of skin
  • urticaria
  • back pain
  • pain in extremities
  • dizziness
  • skin rash
  • flushing
  • headache disorder
  • wheezing
  • dyspnea
  • cough
  • nausea
  • anaphylaxis
  • hypersensitivity drug reaction
  • basal cell carcinoma of skin
  • drug-exacerbated psoriasis
  • cellulitis
  • squamous cell carcinoma of skin

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: TNF blocking agents (such as adalimumab, etanercept, infliximab).

The manufacturer recommends that this medication not be used with anakinra, another drug for rheumatoid arthritis.

This medication may interfere with certain lab tests (including certain blood sugar tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.