Nabumetone

generic for Relafen

Nabumetone Side Effects

See also Warning section.

Upset stomach, nausea, vomiting, constipation, diarrhea, gas, dizziness, drowsiness, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if any of these unlikely but serious side effects occur: hearing changes (such as ringing in the ears), mental/mood changes, difficult/painful swallowing, symptoms of heart failure (such as swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).

Get medical help right away if any of these rare but very serious side effects occur: signs of kidney problems (such as change in the amount of urine), unexplained stiff neck.

This drug may rarely cause serious (possibly fatal) liver disease. If you notice any of the following highly unlikely but very serious side effects, stop taking nabumetone and consult your doctor or pharmacist right away: dark urine, persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes or skin.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • body fluid retention
  • hyperkalemia
  • hypokalemia
  • pancytopenia
  • aplastic anemia
  • anemia
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • granulocytopenic disorder
  • neutropenic disorder
  • acute confusion
  • mood changes
  • agitation
  • depression
  • diplopia
  • blurred vision
  • visual changes
  • tinnitus
  • hypertension
  • acute myocardial infarction
  • angina
  • cardiac arrhythmia
  • cerebrovascular accident
  • vasculitis
  • thrombophlebitis
  • laryngeal edema
  • interstitial pneumonitis
  • Loffler syndrome
  • bronchospastic pulmonary disease
  • xerostomia
  • aphthous stomatitis
  • glossitis
  • esophageal ulcer
  • gastric ulcer
  • duodenal ulcer
  • peptic ulcer
  • gastrointestinal ulcer
  • gastritis
  • dyspepsia
  • gastroenteritis
  • constipation
  • hepatic failure
  • hepatitis
  • bloody stools
  • black tarry stools
  • gastrointestinal hemorrhage
  • interstitial nephritis
  • nephrotoxicity
  • skin photosensitivity
  • allergic dermatitis
  • bullous dermatitis
  • erythema multiforme
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • pruritus of skin
  • acne vulgaris
  • urticaria
  • drowsy
  • altered mental status
  • syncope
  • vertigo
  • dizziness
  • insomnia
  • fever
  • fatigue
  • hyperhidrosis
  • tremor
  • dysgeusia
  • skin rash
  • edema
  • anorexia
  • weight gain
  • increased appetite
  • headache disorder
  • palpitations
  • wheezing
  • dyspnea
  • chest pain
  • chest tightness
  • nausea
  • vomiting
  • bloody vomit
  • dysphagia
  • flatulence
  • diarrhea
  • hyperuricemia
  • hyperglycemia
  • proteinuria
  • abnormal hepatic function tests
  • nervousness
  • anaphylaxis
  • angioedema
  • paresthesia
  • general weakness
  • malaise
  • acute abdominal pain
  • gastrointestinal perforation
  • jaundice

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as prednisone), lithium, methotrexate, "water pills" (diuretics such as furosemide).

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as celecoxib, ibuprofen, or ketorolac). These drugs are similar to nabumetone and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.