Macrodantin

brand

Macrodantin Side Effects

Nausea, vomiting, loss of appetite, or headache may occur. Take this medication with food to help minimize nausea. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

This medication may cause your urine to turn dark yellow or brown in color. This effect is harmless and will disappear when the medication is stopped.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may rarely cause very serious (possibly fatal) lung problems. Lung problems may occur within the first month of treatment or after long-term use of nitrofurantoin (generally for 6 months or longer). Get medical help right away if you develop symptoms of lung problems, including: persistent cough, chest pain, shortness of breath/trouble breathing, joint/muscle pain, bluish/purplish skin.

Tell your doctor right away if any of these rare but very serious side effects occur: new signs of infection (e.g., fever, persistent sore throat), easy bruising/bleeding, mental/mood changes, persistent or severe headaches, vision changes.

This drug may rarely cause serious (possibly fatal) liver disease, blood or nerve problems. Tell your doctor right away if you notice any of the following rare but very serious side effects: persistent nausea/vomiting, dark urine, yellowing of eyes/skin, unusual/persistent fatigue, fast/pounding heartbeat, numbness/tingling of the arms/legs, muscle weakness.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (e.g., oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • Clostridioides difficile infection
  • megaloblastic anemia
  • glucose-6-phosphate dehydrogenase (G6PD) deficiency anemia
  • hemolytic anemia
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • granulocytopenic disorder
  • neutropenic disorder
  • methemoglobinemia
  • idiopathic intracranial hypertension
  • polyneuropathy
  • peripheral neuropathy
  • amblyopia
  • nystagmus
  • optic neuritis
  • vasculitis
  • interstitial pneumonitis
  • pulmonary fibrosis
  • sialoadenitis
  • dyspepsia
  • constipation
  • hepatic necrosis
  • hepatitis
  • obstructive hyperbilirubinemia
  • allergic dermatitis
  • erythema multiforme
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • pruritus of skin
  • alopecia
  • urticaria
  • lupus-like syndrome
  • drowsy
  • vertigo
  • dizziness
  • fever
  • chills
  • skin rash
  • anorexia
  • headache disorder
  • nausea
  • vomiting
  • flatulence
  • diarrhea
  • urine discoloration
  • anaphylaxis
  • general weakness
  • malaise
  • acute abdominal pain
  • pancreatitis
  • increased alanine transaminase
  • increased aspartate transaminase

Drug Interactions

See also the How to Use section.

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: sulfinpyrazone.

This drug can affect the results of certain urine glucose tests (cupric sulfate-type). Make sure laboratory personnel and your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.