LOTREL Side Effects

Dizziness or light-headedness may occur as your body adjusts to the medication. Dry cough or swelling hands/ankles/feet may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these serious side effects occur: fainting, fast/irregular/pounding heartbeat, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), signs of kidney problems (such as change in the amount of urine).

This product may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

Some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Get medical help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • infection
  • hyperkalemia
  • hemolytic anemia
  • thrombocytopenic disorder
  • agranulocytosis
  • neutropenic disorder
  • libido changes
  • vision loss
  • angina
  • cardiac arrhythmia
  • orthostatic hypotension
  • hypotension
  • sinusitis
  • laryngeal edema
  • bronchitis
  • asthma
  • hypersensitivity pneumonitis
  • gastritis
  • constipation
  • drug-induced hepatitis
  • obstructive hyperbilirubinemia
  • acute pancreatitis
  • black tarry stools
  • acute renal failure
  • urinary tract infection
  • erectile dysfunction
  • skin photosensitivity
  • pemphigus
  • Stevens-Johnson syndrome
  • pruritus of skin
  • alopecia
  • arthritis
  • arthralgia
  • hypertonia
  • myalgia
  • drowsy
  • dizziness
  • insomnia
  • fatigue
  • hyperhidrosis
  • dysgeusia
  • skin rash
  • flushing
  • headache disorder
  • dyspnea
  • cough
  • nausea
  • vomiting
  • increased urinary frequency
  • abnormal hepatic function tests
  • nervousness
  • anaphylaxis
  • angioedema
  • paresthesia
  • general weakness
  • intestinal angioedema
  • head and neck angioedema
  • symptoms of anxiety
  • purpura
  • thrombocytopenic disorder
  • leukopenia
  • depersonalization
  • abnormal sexual function
  • depression
  • extrapyramidal disease
  • peripheral neuropathy
  • visual changes
  • conjunctivitis
  • ocular pain
  • tinnitus
  • acute myocardial infarction
  • progressive angina pectoris
  • ventricular tachycardia
  • atrial fibrillation
  • bradycardia
  • vasculitis
  • hypotension
  • peripheral ischemia
  • gingival hyperplasia
  • xerostomia
  • constipation
  • gynecomastia
  • erythema multiforme
  • pruritus of skin
  • osteoarthritis
  • arthralgia
  • back pain
  • myalgia
  • cramps
  • drowsy
  • syncope
  • vertigo
  • dizziness
  • insomnia
  • fatigue
  • hyperhidrosis
  • chills
  • tremor
  • hypesthesia
  • skin rash

Drug Interactions

See also Precautions section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aliskiren, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), lithium, drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone), gold injections, sacubitril.

Some products have ingredients that could raise your blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking benazepril. Make sure all your doctors know which medicines you are using.