Ibu Side Effects

See also Warning section.

Upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, hearing changes (such as ringing in the ears), mental/mood changes, unexplained stiff neck, signs of kidney problems (such as change in the amount of urine), vision changes, symptoms of heart failure (such as swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: dark urine, persistent nausea/vomiting/loss of appetite, stomach/abdominal pain, yellowing eyes/skin.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • non-infective meningitis
  • body fluid retention
  • hyperkalemia
  • hemolytic anemia
  • pancytopenia
  • aplastic anemia
  • anemia
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • neutropenic disorder
  • eosinophilia
  • acute confusion
  • mood changes
  • depression
  • peripheral neuropathy
  • diplopia
  • scotomata
  • blurred vision
  • visual changes
  • conjunctivitis
  • dry eye
  • toxic amblyopia
  • tinnitus
  • hearing loss
  • hypertension
  • acute myocardial infarction
  • cardiac arrhythmia
  • chronic heart failure
  • cerebrovascular accident
  • vasculitis
  • ecchymosis
  • rhinitis
  • laryngeal edema
  • bronchospastic pulmonary disease
  • xerostomia
  • aphthous stomatitis
  • mouth irritation
  • esophageal ulcer
  • gastric ulcer
  • peptic ulcer
  • gastrointestinal ulcer
  • gastritis
  • gastric acid hypersecretory conditions
  • dyspepsia
  • constipation
  • hepatitis
  • drug-induced hepatitis
  • acute pancreatitis
  • bloody stools
  • gastrointestinal hemorrhage
  • nephrotoxicity
  • renal tubular necrosis
  • renal failure
  • renal papillary necrosis
  • kidney disease with reduction in glomerular filtration rate (GFR)
  • cystitis
  • hematuria
  • abnormal vaginal bleeding
  • skin photosensitivity
  • allergic dermatitis
  • bullous dermatitis
  • erythema multiforme
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • pruritus of skin
  • urticaria
  • lupus-like syndrome
  • drowsy
  • altered mental status
  • hallucinations
  • dizziness
  • insomnia
  • skin rash
  • edema
  • flushing
  • anorexia
  • headache disorder
  • epistaxis
  • palpitations
  • wheezing
  • dyspnea
  • chest pain
  • chest tightness
  • nausea
  • vomiting
  • bloody vomit
  • heartburn
  • flatulence
  • diarrhea
  • polyuria
  • abnormal hepatic function tests
  • nervousness
  • anaphylaxis
  • angioedema
  • serum sickness
  • irritability
  • acute abdominal pain
  • gastrointestinal perforation

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as prednisone), lithium, "water pills" (diuretics such as furosemide).

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (including aspirin, NSAIDs such as celecoxib, ketorolac, or naproxen). These drugs are similar to ibuprofen and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Daily use of ibuprofen may decrease aspirin's ability to prevent heart attack/stroke. Talk to your doctor about using a different medication (such as acetaminophen) to treat pain/fever. If you must take ibuprofen, talk to your doctor about taking immediate-release aspirin (not enteric-coated/EC) while taking ibuprofen. Take ibuprofen at least 8 hours before or at least 2 hours after your aspirin dose. Do not increase your daily dose of aspirin or change the way you take aspirin/other medications without your doctor's approval.