Hydrochlorothiazide

generic

Hydrochlorothiazide Side Effects

Upset stomach, dizziness, or headache may occur as your body adjusts to the medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: decrease in vision, eye pain.

This medication may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor right away if you have any symptoms of dehydration or mineral loss, including: extreme thirst, very dry mouth, muscle cramps/weakness, slow/fast/irregular heartbeat, confusion, decreased urination.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • hyperparathyroidism
  • hypercholesterolemia
  • hypertriglyceridemia
  • gout
  • hypomagnesemia
  • hypercalcemia
  • hyponatremia
  • hypokalemia
  • hemolytic anemia
  • aplastic anemia
  • purpura
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • neutropenic disorder
  • abnormal sexual function
  • myopia
  • xanthopsia
  • blurred vision
  • hypersensitivity angiitis
  • vasculitis
  • orthostatic hypotension
  • hypotension
  • interstitial pneumonitis
  • sialoadenitis
  • gastrointestinal irritation
  • constipation
  • hepatitis
  • obstructive hyperbilirubinemia
  • acute pancreatitis
  • interstitial nephritis
  • kidney disease with reduction in glomerular filtration rate (GFR)
  • erectile dysfunction
  • erythema multiforme
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • urticaria
  • systemic lupus erythematosus
  • muscle spasm
  • vertigo
  • dizziness
  • fever
  • fatigue
  • skin rash
  • anorexia
  • headache disorder
  • nausea
  • vomiting
  • diarrhea
  • abdominal pain with cramps
  • hyperuricemia
  • hyperglycemia
  • nervousness
  • anaphylaxis
  • secondary angle-closure glaucoma
  • paresthesia
  • general weakness
  • basal cell carcinoma of skin
  • jaundice
  • hypochloremic alkalosis
  • squamous cell carcinoma of skin

Drug Interactions

See also How To Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: dofetilide, lithium.

Some products have ingredients that could raise your blood pressure or worsen your swelling. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

This medication may interfere with certain lab tests (such as parathyroid function), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.