generic for Aricept

Donepezil Side Effects

Nausea, vomiting, diarrhea, loss of appetite/weight loss, dizziness, drowsiness, weakness, trouble sleeping, shakiness (tremor), or muscle cramps may occur as your body adjusts to the drug. These effects usually last 1-3 weeks and then lessen. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these serious side effects occur: trouble urinating, severe stomach/abdominal pain, black stools, vomit that looks like coffee grounds, seizures.

Get medical help right away if you have any very serious side effects, including: slow/fast/irregular heartbeat, severe dizziness, fainting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • dehydration
  • anemia
  • mood changes
  • delusional disorder
  • libido changes
  • nightmares
  • depression
  • aggressive behavior
  • neuroleptic malignant syndrome
  • cataracts
  • blurred vision
  • ocular irritation
  • hypertension
  • heart block
  • torsades de pointes
  • atrial fibrillation
  • bradycardia
  • prolonged QT interval
  • heart failure
  • hypotension
  • ecchymosis
  • vasodilation of blood vessels
  • bronchitis
  • gastrointestinal hemorrhage
  • genitourinary tract infections
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • pruritus of skin
  • urticaria
  • arthritis
  • rhabdomyolysis
  • cramps
  • drowsy
  • altered mental status
  • syncope
  • seizure disorder
  • vertigo
  • dizziness
  • insomnia
  • fatigue
  • hyperhidrosis
  • pain
  • tremor
  • ataxia
  • peripheral edema
  • anorexia
  • weight loss
  • headache disorder
  • aphasia
  • dyspnea
  • chest pain
  • nausea
  • vomiting
  • flatulence
  • fecal incontinence
  • diarrhea
  • urinary incontinence
  • increased urinary frequency
  • nocturia
  • abdominal pain with cramps
  • abnormal hepatic function tests
  • nervousness
  • paresthesia
  • irritability
  • DRESS syndrome
  • drug-induced hot flash

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aspirin/non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen, naproxen).

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, or naproxen) that if taken together with donepezil may increase your risk for stomach/intestinal bleeding. Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day), should be continued. Consult your doctor or pharmacist for more details.