Chlordiazepoxide / Amitriptyline

generic

Chlordiazepoxide / Amitriptyline Warnings

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition.

Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

Taking chlordiazepoxide with opioid medications (such as codeine, hydrocodone) may increase your risk of very serious side effects, including death. To lower your risk, your doctor should have you take the smallest dose of chlordiazepoxide that works, and take it for the shortest possible time. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up.
  • May cause drowsiness and dizziness. Alcohol and marijuana may intensify this effect. Use care when operating a vehicle, vessel (e.g., boat), or machinery.
  • Do not use this drug if you become pregnant.
  • Call your doctor immediately if you have mental/mood changes like confusion, new/worsening feelings of sadness/fear, thoughts of suicide, or unusual behavior.
  • May cause blurred vision
  • Avoid prolonged or excessive exposure to direct and/or artificial sunlight while using this medication.
  • Consult your doctor or pharmacist before breastfeeding.
  • It is very important that you take or use this exactly as directed. Do not skip doses or discontinue unless directed by your doctor.
  • CAUTION: Ask your doctor before using this drug with opioids (such as codeine, morphine, oxycodone). Serious breathing problems or severe drowsiness may occur.
  • Read the boxed warning information for this medication.

Lactation Warnings

  • INSUFFICIENT DATA AVAIL; LOW MW, EXCRETION IS POSSIBLE; NOT REC PER BRIGGS
  • INSUFFICIENT HUMAN DATA AVAILABLE; LOW LEVELS EXCRETED

Pregnancy Warnings

  • Should be avoided espec during 1st trimester;risk of congenital malformat
  • Use w/caution;active metabolite nortriptyline may cause infant urinary retention