What is Ceftriaxone?

Common Brand(s): Rocephin

Ceftriaxone is used to treat a wide variety of bacterial infections. This medication belongs to a class of drugs known as cephalosporin antibiotics. It works by stopping the growth of bacteria.

This drug is not recommended for use in newborns with high blood bilirubin levels and premature infants due to increased risk of side effects. Ask the doctor or pharmacist for details.


  • Yersinia pseudotuberculosis infection
  • meningococcal meningitis
  • prevention of meningococcal meningitis
  • streptococcal septicemia
  • staphylococcal septicemia
  • Haemophilus septicemia
  • E. coli septicemia
  • Klebsiella pneumoniae septicemia
  • Salmonella septicemia
  • bacterial sepsis
  • Haemophilus influenzae type B infection
  • Lyme disease
  • Lyme arthritis
  • Lyme carditis
  • acute lower genitourinary gonorrhea
  • acute gonococcal urethritis
  • acute gonococcal cervicitis
  • acute gonococcal endometritis
  • adult gonococcal conjunctivitis
  • gonococcal arthritis
  • gonococcal pharyngitis
  • rectal gonorrhea
  • gonococcal meningitis
  • gonococcal endocarditis
  • disseminated gonococcal infection
  • chancroid
  • H. influenzae meningitis
  • pneumococcal meningitis
  • streptococcal meningitis
  • staphylococcal meningitis
  • Escherichia coli meningitis
  • meningitis due to Klebsiella
  • acute bacterial otitis media
  • prevention of bacterial endocarditis
  • streptococcal endocarditis
  • enterococcal endocarditis
  • Haemophilus endocarditis
  • Klebsiella pneumonia
  • Haemophilus influenzae pneumonia
  • Haemophilus parainfluenza pneumonia
  • streptococcal pneumonia
  • staphylococcal pneumonia
  • Escherichia coli pneumonia
  • gram-negative aerobic bacillary pneumonia
  • Serratia pneumonia
  • Enterobacter pneumonia
  • Proteus pneumonia
  • bacterial pneumonia
  • lower respiratory infection
  • E. coli peritonitis
  • Klebsiella pneumoniae peritonitis
  • Peptostreptococcus peritonitis
  • infectious disease of abdomen
  • E. coli urinary tract infection
  • Klebsiella urinary tract infection
  • Proteus urinary tract infection
  • Enterobacter complicated UTI
  • inflammatory disease of female pelvic organs
  • female genital tract infection
  • pelvic inflammatory disease with Neisseria gonorrhea
  • endometritis
  • skin and skin structure infection
  • skin and skin structure Streptococcus pyogenes infection
  • skin and skin structure E. coli infection
  • skin and skin structure Proteus infection
  • skin and skin structure Klebsiella infection
  • skin and skin structure Peptostreptococcus infection
  • skin and skin structure Enterobacter infection
  • skin and skin structure Serratia infection
  • skin and skin structure Morganella morganii infection
  • septic arthritis
  • E. coli septic arthritis
  • Haemophilus septic arthritis
  • Klebsiella joint infection
  • Enterobacter joint infection
  • streptococcal joint infection
  • E. coli joint infection
  • Proteus joint infection
  • infectious disorder of joint
  • Klebsiella pneumoniae osteomyelitis
  • Proteus mirabilis osteomyelitis
  • Streptococcus osteomyelitis
  • E. coli osteomyelitis
  • Enterobacter osteomyelitis
  • Haemophilus osteomyelitis
  • bone infection
  • prevention of perioperative infection
  • infection by Yersinia enterocolitica
  • pediatric fever without a source
  • bacterial meningitis
  • bacterial urinary tract infection
  • lyme disease of the central nervous system

Usage Instructions

This medication is given by injection into a muscle or vein as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment. Drink plenty of fluids while using this medication unless your doctor directs you otherwise.

If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Avoid mixing ceftriaxone with IV fluids that have calcium in them (such as Ringer's solution, Hartmann's solution, parenteral nutrition-TPN/PPN). Consult your pharmacist for details about the safe use of IV calcium products in infants, children, and adults (see Precautions section). Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

If you are using the frozen pre-mixed solution, thaw the bag at room temperature or in the refrigerator. If the bag is thawed in the refrigerator, let it sit at room temperature at least 1 hour before using. Do not thaw by putting in a water bath or microwaving. After thawing, shake well and squeeze the bag to check for leaks. Discard solution if the bag leaks. Do not re-freeze the solution after thawing.

For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same time(s) every day.

Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.


Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.