Azulfidine EN-tabs

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Azulfidine EN-tabs Side Effects

Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

This medication may cause your skin and urine to turn orange-yellow. This effect is harmless and will disappear when the medication is stopped.

Rarely, delayed-release tablets of sulfasalazine may appear whole or only partly dissolved in your stool. If this occurs, tell your doctor right away so your treatment can be changed.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: hearing changes (e.g., ringing in the ears), mental/mood changes, signs of kidney problems (such as change in the amount of urine, painful urination, blood in the urine), new lump/growth in the neck (goiter), numbness/tingling of the hands/feet, signs of low blood sugar (e.g., hunger, cold sweat, blurred vision, weakness, fast heartbeat).

This medication may rarely cause very serious allergic reactions (e.g., Stevens-Johnson syndrome), blood disorders (e.g., agranulocytosis, aplastic anemia), liver damage, nerve/muscle problems and infections. Get medical help right away if you have any very serious side effects, including: skin rash/blisters/peeling, mouth sores, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, chest pain, signs of infection (such as fever, chills, persistent sore throat, cough), swollen lymph nodes, easy bruising/bleeding, severe tiredness, muscle pain/weakness (especially with fever and unusual tiredness), pale or blue skin/lips/nails, new/worsening joint pain, confusion, persistent/severe headache, unexplained neck stiffness, seizures, signs of liver problems (e.g., persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes/skin, dark urine).

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • glucose-6-phosphate dehydrogenase (G6PD) deficiency anemia
  • hemolytic anemia
  • hemolytic uremic syndrome
  • aplastic anemia
  • hypoprothrombinemia
  • purpura
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • neutropenic disorder
  • eosinophilia
  • methemoglobinemia
  • blood dyscrasias
  • myelitis
  • peripheral neuropathy
  • periorbital edema
  • hearing loss
  • myocarditis
  • pneumonia
  • interstitial pneumonitis
  • alveolitis
  • eosinophilic pneumonia
  • stomatitis
  • dyspepsia
  • ulcerative colitis
  • enterocolitis
  • hepatic necrosis
  • hepatocellular damage
  • hepatic failure
  • hepatitis
  • obstructive hyperbilirubinemia
  • nephrotic syndrome
  • nephritis
  • kidney stone
  • kidney disease with reduction in glomerular filtration rate (GFR)
  • urinary tract infection
  • hematuria
  • oligospermia
  • skin photosensitivity
  • allergic dermatitis
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • pruritus of skin
  • alopecia
  • urticaria
  • dyschromia
  • rhabdomyolysis
  • myelodysplastic syndrome
  • drowsy
  • hallucinations
  • vertigo
  • dizziness
  • insomnia
  • drug fever
  • ataxia
  • skin rash
  • cyanosis
  • anorexia
  • headache disorder
  • nausea
  • vomiting
  • diarrhea
  • abdominal pain with cramps
  • proteinuria
  • crystalluria
  • urine discoloration
  • abnormal hepatic function tests
  • anaphylaxis
  • angioedema
  • serum sickness
  • pancreatitis
  • sepsis

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: digoxin, folic acid, methenamine, PABA taken by mouth.

Sulfasalazine is very similar to mesalamine. Do not use mesalamine medications taken by mouth while using sulfasalazine.

This medication may interfere with certain laboratory tests (including urine normetanephrine levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.