Atovaquone / Proguanil

generic for Malarone

Atovaquone / Proguanil Side Effects

See also How to Use section.

Side effects may include nausea, vomiting, abdominal pain, headache, diarrhea, weakness, loss of appetite, and dizziness. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these rare but very serious side effects occur: signs of serious liver problems (such as persistent/severe nausea and vomiting, abdominal pain, unexplained tiredness, dark urine, yellowing eyes/skin), signs of anemia (such as worsening tiredness, rapid breathing, pale skin/lips/nails, fast heartbeat while resting), signs of severe infection (such as high fever, severe chills, body aches, sore throat).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • neutropenic disorder
  • visual changes
  • hypersensitivity angiitis
  • upper respiratory infection
  • stomatitis
  • aphthous stomatitis
  • gastritis
  • dyspepsia
  • hepatitis
  • skin photosensitivity
  • erythema multiforme
  • Stevens-Johnson syndrome
  • pruritus of skin
  • urticaria
  • back pain
  • myalgia
  • dizziness
  • insomnia
  • fever
  • flu-like symptoms
  • skin rash
  • anorexia
  • headache disorder
  • cough
  • nausea
  • vomiting
  • diarrhea
  • abdominal pain with cramps
  • abnormal hepatic function tests
  • anaphylaxis
  • angioedema
  • general weakness

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: penicillamine, "blood thinners" (such as warfarin), metoclopramide.

Other medications can affect the removal of atovaquone/proguanil from your body, which may affect how atovaquone/proguanil works. Examples include efavirenz, rifampin, rifabutin, tetracycline, among others.