Aspirin / Omeprazole

generic for Yosprala

Aspirin / Omeprazole Side Effects

Upset stomach or heartburn may occur. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, unusual tiredness, signs of kidney problems (such as change in the amount of urine), signs of liver problems (such as nausea/vomiting that doesn't stop, loss of appetite, yellowing eyes/skin, dark urine), symptoms of a low magnesium blood level (such as muscle spasms that don't go away, fast/slow/irregular heartbeat, seizures), signs of lupus (such as rash on nose and cheeks, new or worsening joint pain).

This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. If you notice any of the following unlikely but serious side effects, stop taking this medication and consult your doctor or pharmacist right away: stomach/abdominal pain that doesn't go away, black stools, vomit that looks like coffee grounds.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of bacteria. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, fever, blood/mucus in your stool.

Rarely, proton pump inhibitors (such as omeprazole) have caused vitamin B-12 deficiency. The risk is increased if they are taken every day for a long time (3 years or longer). Tell your doctor right away if you develop symptoms of vitamin B-12 deficiency (such as unusual weakness, sore tongue, or numbness/tingling of the hands/feet).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • Clostridioides difficile infection
  • esophageal candidiasis
  • hypoglycemic disorder
  • vitamin B12 deficiency
  • hypomagnesemia
  • hyponatremia
  • pancytopenia
  • anemia
  • purpura
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • neutropenic disorder
  • leukocytosis
  • diplopia
  • blurred vision
  • dry eye
  • optic neuritis
  • ocular irritation
  • tinnitus
  • hypertension
  • bradycardia
  • cardiac arrhythmia
  • sore throat
  • upper respiratory infection
  • bronchospastic pulmonary disease
  • xerostomia
  • stomatitis
  • constipation
  • irritable bowel syndrome
  • hepatic failure
  • hepatitis
  • interstitial nephritis
  • urinary tract infection
  • hematuria
  • gynecomastia
  • skin inflammation
  • skin photosensitivity
  • erythema multiforme
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • subacute cutaneous lupus erythematosus
  • pruritus of skin
  • alopecia
  • dry skin
  • urticaria
  • systemic lupus erythematosus
  • arthralgia
  • back pain
  • muscle weakness
  • myalgia
  • cramps
  • vertigo
  • dizziness
  • sleep disorder
  • fever
  • fatigue
  • hyperhidrosis
  • pain
  • tremor
  • dysgeusia
  • skin rash
  • peripheral edema
  • hyperbilirubinemia
  • petechiae
  • anorexia
  • weight gain
  • headache disorder
  • epistaxis
  • palpitations
  • cough
  • chest pain
  • nausea
  • vomiting
  • flatulence
  • discolored feces
  • diarrhea
  • abdominal distension
  • proteinuria
  • glycosuria
  • abnormal hepatic function tests
  • fracture
  • anaphylaxis
  • angioedema
  • paresthesia
  • cholestatic hepatitis
  • general weakness
  • malaise
  • acute abdominal pain
  • anterior ischemic optic neuropathy
  • pancreatitis
  • atrophic gastritis
  • testicular pain
  • benign fundic gland polyposis of stomach
  • leg pain
  • tachycardia
  • increased alanine transaminase
  • increased aspartate transaminase
  • hemolytic anemia
  • anemia

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: corticosteroids (such as prednisone), methotrexate (especially high-dose treatment), mifepristone, ginkgo biloba, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, ticagrelor, NSAIDs such as ibuprofen/naproxen, "blood thinners" such as warfarin/dabigatran).

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen or naproxen). These drugs are similar to this medication and may increase your risk of side effects if taken together. Ask your doctor or pharmacist for more details.

Some products need stomach acid so that the body can absorb them properly. Omeprazole decreases stomach acid, so it may change how well these products work. Some affected products include atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others.

Other medications can affect the removal of omeprazole from your body, which may affect how this product works. Examples include rifampin, St John's wort, among others.

Omeprazole is very similar to esomeprazole. Do not use any medications containing esomeprazole while using omeprazole.

This medication may interfere with certain lab or medical tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.