Arsenic trioxide

generic for Trisenox

Arsenic trioxide Warnings

Arsenic trioxide is a strong medication that can cause serious, rarely fatal side effects. To decrease your risk, your doctor will monitor you closely during treatment.

Rarely, this medication may cause a serious condition called APL differentiation syndrome. Tell your doctor right away if the following effects occur: unusual/unexplained fever, shortness of breath/difficulty breathing, and/or weight gain. Your doctor may direct you to weigh yourself regularly and report any sudden weight gain. Your doctor may also perform certain exams or tests (e.g., lung exam, X-rays) to determine if this syndrome has developed.

Rarely, this medication can also cause serious (rarely fatal) heart problems (e.g., AV block, torsades de pointes-type arrhythmias). Tell your doctor if you have any medical history of heart problems (e.g., fast/irregular heartbeat, heart failure), kidney problems, low levels of minerals in your blood (e.g., calcium, potassium, magnesium). Also tell your doctor if you take any medications that increase your risk for these heart problems or low levels of minerals (see also Drug Interactions section). To decrease your risk, your doctor may order a heart rhythm test (EKG) or blood tests before and during treatment.

Get medical help right away if you develop severe dizziness, fainting, or fast/irregular heartbeat.

This medication may increase your risk of getting a rare but very serious (possibly fatal) brain disorder. This risk may be higher if you have low levels of thiamine (vitamin B1), alcohol use disorder, or difficulty absorbing nutrition from food (malabsorption syndrome). Get medical help right away if you have any of these side effects: clumsiness, loss of coordination/balance, weakness, sudden change in your thinking (such as confusion, difficulty concentrating, memory loss), difficulty talking/walking, seizures, vision changes.
  • Warning: Do not use if you are pregnant, suspect that you are pregnant, or while breastfeeding. Consult your doctor or pharmacist.
  • May cause dizziness
  • This drug may impair the ability to operate a vehicle, vessel (e.g., boat), or machinery. Use care until you become familiar with its effects.
  • CAUTION. Follow procedures for proper handling and disposal of hazardous drugs.
  • Read the boxed warning information for this medication.

Lactation Warnings

  • INSUFF HUMAN DATA AVAIL; MAY CAUSE SERIOUS ADVERSE EFFECT IN NURSING INFANT

Pregnancy Warnings

  • Limited human data available. Animal data suggest developmental toxicity at doses 10 times the maximum recommended human dose. Inform pregnant patient of the possible risk to a fetus Consider maternal treatment benefits versus potential fetal/neonatal adverse outcomes.