Arsenic trioxide

generic for Trisenox

Arsenic trioxide Side Effects

See also Warning section.

Pain/redness/swelling at the injection site, nausea, vomiting, diarrhea, stomach/abdominal pain, tiredness, cough, headache, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

Both leukemia and this medication can lower the body's ability to fight an infection. Tell your doctor promptly if you develop any signs of an infection such as unexplained fever, chills, or persistent sore throat.

Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, nosebleed, increased thirst, signs of kidney problems (such as change in the amount of urine), bone/joint pain, decreased appetite, unusual weight loss, muscle pain/stiffness/spasm, numbness/tingling, swollen hands/legs/feet, symptoms of liver disease (such as nausea/vomiting that doesn't stop, severe stomach/abdominal pain, yellowing eyes/skin, dark urine).

Get medical help right away if you have any very serious side effects, including: chest pain, severe dizziness/fainting, fast/irregular heartbeat, coughing up blood, mental/mood changes (e.g., confusion), muscle weakness, bloody/black/tarry stool, vomit that looks like coffee grounds.

People who are treated with this medication may rarely get other cancers. Consult your doctor for more details.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice any other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • herpes zoster
  • oral candidiasis
  • malignant melanoma
  • adenocarcinoma of pancreas
  • squamous cell carcinoma
  • hypoglycemic disorder
  • hypomagnesemia
  • hypocalcemia
  • acidosis
  • hyperkalemia
  • hypokalemia
  • pancytopenia
  • anemia
  • disseminated intravascular coagulation
  • thrombocytopenic disorder
  • neutropenic disorder
  • leukocytosis
  • acute confusion
  • agitation
  • depression
  • encephalopathy
  • peripheral neuropathy
  • blurred vision
  • dry eye
  • ocular pain
  • tinnitus
  • earache
  • hearing loss
  • hypertension
  • atrioventricular block
  • ventricular tachycardia
  • torsades de pointes
  • ventricular premature beats
  • prolonged QT interval
  • hemorrhage
  • ecchymosis
  • sore throat
  • upper respiratory infection
  • sinusitis
  • pleural effusions
  • xerostomia
  • dyspepsia
  • constipation
  • gastrointestinal hemorrhage
  • kidney disease with reduction in glomerular filtration rate (GFR)
  • abnormal vaginal bleeding
  • allergic dermatitis
  • toxic epidermal necrolysis
  • pruritus of skin
  • arthralgia
  • neck pain
  • back pain
  • rhabdomyolysis
  • myalgia
  • pain in extremities
  • bone pain
  • coma
  • seizure disorder
  • dizziness
  • insomnia
  • fever
  • fatigue
  • hyperhidrosis
  • chills
  • tremor
  • edema
  • facial edema
  • hyperbilirubinemia
  • pallor
  • flushing
  • petechiae
  • anorexia
  • weight gain
  • weight loss
  • headache disorder
  • epistaxis
  • palpitations
  • lymphadenopathy
  • tachypnea
  • wheezing
  • dyspnea
  • cough
  • hemoptysis
  • chest pain
  • nausea
  • vomiting
  • fecal incontinence
  • diarrhea
  • oliguria
  • abdominal distension
  • hyperglycemia
  • abnormal hepatic function tests
  • hypoxia
  • injection site sequelae
  • differentiation syndrome in acute promyelocytic leukemia
  • paresthesia
  • Wernicke's encephalopathy
  • acute abdominal pain
  • posterior reversible encephalopathy syndrome
  • symptoms of anxiety

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Many drugs besides arsenic trioxide may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), ziprasidone, among others. Therefore, before using arsenic trioxide, report all medications you are currently using to your doctor or pharmacist.

Some products that may interact with this drug are: aspirin and other NSAIDs (e.g., ibuprofen), drugs that lower blood minerals (e.g., amphotericin B), drugs that may harm the immune system (e.g., chemotherapy).

Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, or aspirin) that may increase your risk of bleeding. Low-dose aspirin should be continued if prescribed by your doctor for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day). Consult your doctor or pharmacist for more details.