Arixtra Warnings

People using this medication may bleed near the spinal cord after certain spinal procedures. Bleeding in this area can cause paralysis that lasts a long time or could become permanent. Talk with your doctor about the benefits and risks before any spinal procedure. Your doctor may direct you to stop this medication for a certain amount of time before and after the procedure. Carefully follow your doctor's directions.

The risk of bleeding may be higher if you have a deformed spine, or have had spinal procedures/surgery before (such as epidural catheter placement, difficult epidural/spinal puncture), or are taking other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/rivaroxaban, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Tell your doctor right away if you notice symptoms such as back pain, leg numbness/tingling/weakness, loss of control of the bowels or bladder (incontinence).

• Do not take aspirin products without doctor approval. Continue taking low-dose aspirin to prevent heart attack/stroke unless doctor tells you to stop.
• Do not take non-prescribed drugs containing aspirin, ibuprofen or naproxen without consent of your physician
• Patients regularly using NSAIDs (e.g. ibuprofen) and this drug may be at a greater risk for stomach bleeding and should consult their physician.
• Immediately report bleeding or bruising to your doctor.
• Read the boxed warning information for this medication.

Lactation Warnings

• INSUFFICIENT HUMAN DATA AVAILABLE; EXCRETED IN RATS

Pregnancy Warnings

• Limited human data do not suggest a clear association for development toxicity or adverse events. Transplacental transfer has been reported. Monitor neonates for bleeding. Animal data suggest no developmental toxicity at doses less than 10 times the maximum recommended human dose.