Amoxicillin / Clavulanate

generic for Augmentin

Amoxicillin / Clavulanate Side Effects

Diarrhea, nausea, or vomiting may occur. If any of these effects persist or worsen, tell the doctor or pharmacist promptly. Taking this medication with food will help to reduce stomach upset.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell the doctor right away if any of these rare but serious side effects occur: dark urine, persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes/skin, easy bruising/bleeding, new signs of infection (such as fever, persistent sore throat), unusual tiredness.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. Tell the doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact the doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Amoxicillin can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Therefore, get medical help right away if you develop any rash.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact the doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • Clostridioides difficile infection
  • oral candidiasis
  • vulvovaginal candidiasis
  • hemolytic anemia
  • pancytopenia
  • anemia
  • increased risk of bleeding due to coagulation disorder
  • qualitative platelet disorder
  • thrombocytopenic disorder
  • agranulocytosis
  • leukopenia
  • neutropenic disorder
  • eosinophilia
  • thrombocytosis
  • acute confusion
  • agitation
  • hypersensitivity angiitis
  • thrombophlebitis
  • thrombotic thrombocytopenic purpura
  • hypotension
  • eosinophilic pneumonia
  • dental discoloration
  • stomatitis
  • glossitis
  • gastritis
  • dyspepsia
  • gastrointestinal irritation
  • constipation
  • hepatitis
  • disease of liver
  • obstructive hyperbilirubinemia
  • cholestasis
  • black tarry stools
  • interstitial nephritis
  • kidney disease with reduction in glomerular filtration rate (GFR)
  • hematuria
  • erythema multiforme
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • pruritus of skin
  • urticaria
  • back pain
  • myalgia
  • seizure disorder
  • dizziness
  • insomnia
  • fever
  • chills
  • tremor
  • dysgeusia
  • skin rash
  • edema
  • hyperbilirubinemia
  • headache disorder
  • dyspnea
  • nausea
  • vomiting
  • flatulence
  • loose stools
  • diarrhea
  • crystalluria
  • abnormal hepatic function tests
  • anaphylaxis
  • angioedema
  • hypersensitivity drug reaction
  • serum sickness
  • injection site sequelae
  • cholestatic hepatitis
  • mucocutaneous candidiasis
  • acute abdominal pain
  • jaundice
  • furred tongue
  • multiple organ failure
  • acute generalized exanthematous pustulosis
  • DRESS syndrome
  • symptoms of anxiety
  • phlebitis after infusion

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Products that may interact with this drug include: methotrexate.

This medication may interfere with certain laboratory tests (including certain urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.