Agrylin Side Effects

Headache, diarrhea, weakness, nausea, gas, loss of appetite, and dizziness may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: unusual bleeding/bruising, black stools, swelling of the ankles/feet, rapid/difficult breathing, stomach/abdominal pain, unusual tiredness, signs of kidney problems (such as change in the amount of urine, pink/bloody urine), vomit that looks like coffee grounds.

Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, confusion/mental changes, severe dizziness, fainting, fast/irregular/pounding heartbeat, seizures, slurred speech, vision changes, weakness on one side of the body.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

dehydration
anemia
thrombocytopenic disorder
leukocytosis
acute confusion
depression
amblyopia
diplopia
visual changes
tinnitus
hypertension
acute myocardial infarction
angina
pulmonary hypertension
pericarditis
cardiomyopathy
complete atrioventricular block
supraventricular tachycardia
ventricular tachycardia
torsades de pointes
atrial fibrillation
prolonged QT interval
cardiac arrhythmia
chronic heart failure
cardiomegaly
cerebrovascular accident
orthostatic hypotension
hypotension
hemorrhage
ecchymosis
vasodilation of blood vessels
pharyngitis
rhinitis
pneumonia
bronchitis
asthma
pleural effusions
pulmonary fibrosis
pulmonary infiltrates
eosinophilic pneumonia
aphthous stomatitis
gastrointestinal ulcer
gastritis
dyspepsia
constipation
hepatitis
black tarry stools
gastrointestinal hemorrhage
interstitial nephritis
renal failure
hematuria
skin photosensitivity
pruritus of skin
alopecia
arthralgia
back pain
myalgia
cramps in legs
drowsy
memory impairment
syncope
seizure disorder
dizziness
insomnia
fever
flu-like symptoms
pain
chills
hypesthesia
skin rash
edema
peripheral edema
anorexia
headache disorder
epistaxis
palpitations
lymphadenopathy
dyspnea
cough
chest pain
nausea
vomiting
flatulence
eructation
diarrhea
dysuria
abnormal hepatic function tests
nervousness
paresthesia
general weakness
malaise
acute abdominal pain
interstitial lung disease
pancreatitis
tachycardia

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/enoxaparin), sucralfate.

Only take aspirin if your doctor approves of it. Aspirin can increase the risk of bleeding when used with anagrelide, especially if you already have a high risk for bleeding. However, if your doctor has directed you to take low-dose aspirin to prevent blood clots, or for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Discuss the risks and benefits with your doctor or pharmacist.

Many drugs besides anagrelide may affect the heart rhythm (QT prolongation), including amiodarone, chloroquine, clarithromycin, disopyramide, haloperidol, methadone, moxifloxacin, pimozide, procainamide, among others.