Agrylin Side Effects

Headache, diarrhea, weakness, nausea, gas, loss of appetite, and dizziness may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: unusual bleeding/bruising, black stools, swelling of the ankles/feet, rapid/difficult breathing, stomach/abdominal pain, unusual tiredness, signs of kidney problems (such as change in the amount of urine, pink/bloody urine), vomit that looks like coffee grounds.

Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, confusion/mental changes, severe dizziness, fainting, fast/irregular/pounding heartbeat, seizures, slurred speech, vision changes, weakness on one side of the body.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • dehydration
  • anemia
  • thrombocytopenic disorder
  • leukocytosis
  • acute confusion
  • depression
  • amblyopia
  • diplopia
  • visual changes
  • tinnitus
  • hypertension
  • acute myocardial infarction
  • angina
  • pulmonary hypertension
  • pericarditis
  • cardiomyopathy
  • complete atrioventricular block
  • supraventricular tachycardia
  • ventricular tachycardia
  • torsades de pointes
  • atrial fibrillation
  • prolonged QT interval
  • cardiac arrhythmia
  • chronic heart failure
  • cardiomegaly
  • cerebrovascular accident
  • orthostatic hypotension
  • hypotension
  • hemorrhage
  • ecchymosis
  • vasodilation of blood vessels
  • pharyngitis
  • rhinitis
  • pneumonia
  • bronchitis
  • asthma
  • pleural effusions
  • pulmonary fibrosis
  • pulmonary infiltrates
  • eosinophilic pneumonia
  • aphthous stomatitis
  • gastrointestinal ulcer
  • gastritis
  • dyspepsia
  • constipation
  • hepatitis
  • black tarry stools
  • gastrointestinal hemorrhage
  • interstitial nephritis
  • renal failure
  • hematuria
  • skin photosensitivity
  • pruritus of skin
  • alopecia
  • arthralgia
  • back pain
  • myalgia
  • cramps in legs
  • drowsy
  • memory impairment
  • syncope
  • seizure disorder
  • dizziness
  • insomnia
  • fever
  • flu-like symptoms
  • pain
  • chills
  • hypesthesia
  • skin rash
  • edema
  • peripheral edema
  • anorexia
  • headache disorder
  • epistaxis
  • palpitations
  • lymphadenopathy
  • dyspnea
  • cough
  • chest pain
  • nausea
  • vomiting
  • flatulence
  • eructation
  • diarrhea
  • dysuria
  • abnormal hepatic function tests
  • nervousness
  • paresthesia
  • general weakness
  • malaise
  • acute abdominal pain
  • interstitial lung disease
  • pancreatitis
  • tachycardia

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/enoxaparin), sucralfate.

Only take aspirin if your doctor approves of it. Aspirin can increase the risk of bleeding when used with anagrelide, especially if you already have a high risk for bleeding. However, if your doctor has directed you to take low-dose aspirin to prevent blood clots, or for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Discuss the risks and benefits with your doctor or pharmacist.

Many drugs besides anagrelide may affect the heart rhythm (QT prolongation), including amiodarone, chloroquine, clarithromycin, disopyramide, haloperidol, methadone, moxifloxacin, pimozide, procainamide, among others.