What is Afrezza?

Common Brand(s): Afrezza

Inhaled insulin powder is used with a proper diet and exercise program to control high blood sugar in people with diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

This man-made insulin product is the same as human insulin. It replaces the insulin that your body would normally make. It is a short-acting insulin. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. This product is absorbed into the blood through your lungs. It starts working faster and lasts for a shorter time than regular insulin injected under the skin. It is usually used in combination with a medium- or long-acting insulin product. This medication may also be used alone or with other oral diabetes drugs (such as metformin).


  • type 2 diabetes mellitus
  • type 1 diabetes mellitus

Usage Instructions

Read the Medication Guide and Instructions for Use Leaflet provided by your pharmacist before you start using inhaled insulin and each time you get a refill. Follow the illustrated directions for the proper use of this medication. If you have any questions, ask your doctor, diabetes educator, or pharmacist.

This medication comes in cartridges in a blister package. Do not try to open the cartridges. The inhaler opens the blister/cartridge containing the insulin powder, allowing the insulin to be inhaled. Bring the medication and inhaler to room temperature before using. Follow your doctor's directions carefully.

Inhale this medication by mouth at the beginning of a meal as directed by your doctor. Because inhaled insulin is fast-acting, not eating immediately after inhaling a dose of this insulin may lead to low blood sugar.

The dosage is based on your medical condition and response to treatment.

Do not change brands or types of insulin without directions on how to do so from your doctor.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.

Check your blood sugar regularly as directed by your doctor. Keep track of your results and share them with your doctor. This is very important in order to determine the correct insulin dose.

Tell your doctor if your condition does not improve or if it worsens (your blood sugar is too high or too low).


Store the unopened medication in the refrigerator before using. Keep all medications away from children and pets.

Once opened, check the product package for instructions on how to store your medication and inhaler, or ask your pharmacist. Discard the inhaler after 15 days.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.