Actonel Side Effects

Stomach upset may occur. If this effect persists or worsens, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: increased or severe bone/joint/muscle pain, new or unusual hip/thigh/groin pain, jaw pain, eye/vision problems.

This medication may rarely cause irritation and ulcers in your stomach or esophagus. Get medical help right away if any of these serious side effects occur: new/severe/worsening heartburn, chest pain, difficult or painful swallowing, severe stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
  • hypocalcemia
  • depression
  • iritis
  • uveitis
  • cataracts
  • hypertension
  • cardiac arrhythmia
  • pharyngitis
  • rhinitis
  • asthma exacerbation
  • glossitis
  • esophagitis
  • esophageal ulcer
  • esophageal perforation
  • gastrointestinal ulcer
  • gastritis
  • dyspepsia
  • constipation
  • kidney stone
  • urinary tract infection
  • benign prostatic hyperplasia
  • bullous dermatitis
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • arthritis
  • arthralgia
  • neck pain
  • back pain
  • myalgia
  • bone pain
  • dizziness
  • insomnia
  • flu-like symptoms
  • skin rash
  • peripheral edema
  • headache disorder
  • chest pain
  • nausea
  • vomiting
  • dysphagia
  • diarrhea
  • abdominal pain with cramps
  • abnormal hepatic function tests
  • angioedema
  • hypersensitivity drug reaction
  • duodenitis
  • general weakness
  • aseptic necrosis of jaw bone
  • atypical femoral fracture
  • aseptic necrosis of bone in orofacial region

Drug Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

This medication may interfere with certain lab tests (bone-imaging agents). Be sure to tell your doctor or laboratory personnel that you are taking this medication.